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About
What is Reactome ?
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Team
Scientific Advisory Board
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Digital Preservation
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NRG1/2 [extracellular region]
Stable Identifier
R-HSA-1227956
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neuregulins NRG1 and NRG2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants heterodimerize (Homo sapiens)
Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Ligand-Activated (EGFR,ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)
p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3:PI3K [plasma membrane] (Homo sapiens)
p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K (Homo sapiens)
p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3:PI3K [plasma membrane] (Homo sapiens)
p-ERBB2 KD mutants:NRG1/NRG2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,(p-ERBB3,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)
ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
ERBB2 Activates PTK6 Signaling (Homo sapiens)
Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers:MATK [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)
Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Homo sapiens)
Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 Activates PTK6 Signaling (Homo sapiens)
Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 Regulates Cell Motility (Homo sapiens)
MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Ligand-Activated EGFR/ERBB3/ERBB4 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
ERBB3 binds neuregulins (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
GRB7 events in ERBB2 signaling (Homo sapiens)
GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
SHC1 events in ERBB2 signaling (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
SHC1 phosphorylation by ERBB2 heterodimers (Homo sapiens)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
SRC family kinases phosphorylate ERBB2 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:p-Y877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-6Y-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:p-Y877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
ERBB4 forms heterodimers with ERBB3 (Homo sapiens)
ERBB4:ERBB3 heterodimer [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2 [extracellular region] (Homo sapiens)
Participants
members
NRG2 [extracellular region]
(Homo sapiens)
NRG1 [extracellular region]
(Homo sapiens)
Participates
as an input of
ERBB3 binds neuregulins (Homo sapiens)
as a component of
NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3 [plasma membrane] (Homo sapiens)
Inferred To
NRG1/2 [extracellular region]
(Bos taurus)
NRG1/2 [extracellular region]
(Canis familiaris)
NRG1/2 [extracellular region]
(Gallus gallus)
NRG1/2 [extracellular region]
(Mus musculus)
NRG1/2 [extracellular region]
(Rattus norvegicus)
NRG1/2 [extracellular region]
(Sus scrofa)
vn [extracellular region]
(Drosophila melanogaster)
nrg2b [extracellular region]
(Danio rerio)
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