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EGLN2 [nucleoplasm]
Stable Identifier
R-HSA-1234117
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Egl nine homolog 2, EGLN2_HUMAN, PHD1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD1,3 [nucleoplasm] (Homo sapiens)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
EGLN2 [nucleoplasm] (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD1,3 [nucleoplasm] (Homo sapiens)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
EGLN2 [nucleoplasm] (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD1,3 [nucleoplasm] (Homo sapiens)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
EGLN2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96KS0 EGLN2
Gene Names
EGLN2, EIT6
Chain
chain:1-407
Reference Genes
BioGPS Gene:112398 EGLN2
COSMIC (genes):EGLN2 EGLN2
CTD Gene:112398 EGLN2
dbSNP Gene:112398 EGLN2
ENSEMBL:ENSG00000269858 EGLN2
HGNC:14660 EGLN2
KEGG:hsa:112398 EGLN2
Monarch:112398 EGLN2
NCBI Gene:112398 EGLN2
OMIM:606424 EGLN2
UCSC:Q96KS0 EGLN2
Reference Transcript
RefSeq:NM_053046.3 EGLN2
RefSeq:NM_080732.3 EGLN2
Other Identifiers
112398
11744025_a_at
11744026_at
220956_PM_s_at
220956_s_at
223083_PM_s_at
223083_s_at
3833828
3833829
3833830
3833831
3833832
3833833
3833834
3833835
3833836
3833837
3833838
3833839
3833841
3833842
3833843
3833844
3833845
3833846
3833847
3833848
3833849
3833850
3833851
3833852
3833853
3833854
43521_at
46738_at
48748_at
8028940
A_14_P137134
A_24_P322395
GE56573
GO:0001558
GO:0001666
GO:0003824
GO:0005506
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006520
GO:0006575
GO:0008198
GO:0016491
GO:0016705
GO:0016706
GO:0018401
GO:0019826
GO:0030520
GO:0031418
GO:0031545
GO:0043226
GO:0043523
GO:0045454
GO:0045732
GO:0046872
GO:0051213
GO:0071456
GO:0140096
GO:0140299
GO:0160082
HMNXSV003004023
Hs.324277.0.A1_3p_a_at
ILMN_1768773
ILMN_1815686
ILMN_2354391
PH_hs_0016134
TC19002634.hg
g8922129_3p_s_at
p33691
Participates
as a component of
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
Inferred To
EGLN2 [nucleoplasm]
(Bos taurus)
EGLN2 [nucleoplasm]
(Caenorhabditis elegans)
EGLN2 [nucleoplasm]
(Canis familiaris)
EGLN2 [nucleoplasm]
(Mus musculus)
EGLN2 [nucleoplasm]
(Rattus norvegicus)
Hph [nucleoplasm]
(Drosophila melanogaster)
egln2 [nucleoplasm]
(Danio rerio)
egln2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2832
ENSEMBL
ENSP00000385253
,
ENSP00000307080
,
ENST00000303961
,
ENST00000593726
,
ENST00000406058
,
ENSP00000469686
OpenTargets
ENSG00000269858
HPA
ENSG00000269858-EGLN2
ZINC - Substances
EGLN2_HUMAN
ZINC target
Q96KS0
PRO
Q96KS0
Pharos - Targets
Q96KS0
GlyGen
Q96KS0
ZINC - Predictions - Purchasable
EGLN2_HUMAN
HMDB Protein
HMDBP09211
PDB
5V1B
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
0.683
3
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