Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
VHL [nucleoplasm]
Stable Identifier
R-HSA-1234127
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VBC Complex [nucleoplasm] (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of ubiquitinylation proteins (Homo sapiens)
PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)
VHL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40337 VHL
Gene Names
VHL
Chain
chain:1-213
Reference Genes
BioGPS Gene:7428 VHL
COSMIC (genes):VHL VHL
CTD Gene:7428 VHL
dbSNP Gene:7428 VHL
ENSEMBL:ENSG00000134086 VHL
ENSEMBL_homo_sapiens_GENE:ENSG00000134086.9 VHL
HGNC:12687 VHL
KEGG Gene (Homo sapiens):7428 VHL
Monarch:7428 VHL
NCBI Gene:7428 VHL
OMIM:608537 VHL
UCSC:P40337 VHL
Reference Transcript
RefSeq:NM_198156.2 VHL
RefSeq:NM_000551.3 VHL
Other Identifiers
11748633_a_at
11752180_x_at
1559227_PM_s_at
1559227_s_at
1668_s_at
16937571
203844_PM_at
203844_at
2610338
2610339
2610340
2610342
2610344
2610345
2610346
2610347
2610348
2610349
2610350
2610351
2610352
2610353
2610354
40871_at
7428
8077781
A_23_P132606
A_24_P134942
A_33_P3419938
GE54104
GO:0000122
GO:0000902
GO:0003711
GO:0003714
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006508
GO:0006914
GO:0008285
GO:0009968
GO:0010468
GO:0010507
GO:0010629
GO:0012501
GO:0016020
GO:0016567
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030163
GO:0034244
GO:0036211
GO:0043066
GO:0043161
GO:0043226
GO:0043232
GO:0045597
GO:0045893
GO:0046426
GO:0048856
GO:0050821
GO:0060090
GO:0071456
GO:0140096
GO:0140110
GO:0140297
GO:1900037
GO:1904262
GO:1990000
GO:1990756
HMNXSV003025175
Hs2.421597.1.A1_3p_s_at
ILMN_1738579
ILMN_1801984
ILMN_2376625
L15409_at
PH_hs_0033268
TC03000055.hg
TC03002213.hg
g4507890_3p_at
Participates
as an input of
PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)
as a component of
VBC Complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K159,171,196-VHL [nucleoplasm]
VHL [cytosol]
Inferred To
Vhl [nucleoplasm]
(Drosophila melanogaster)
Vhl [nucleoplasm]
(Mus musculus)
Vhl [nucleoplasm]
(Rattus norvegicus)
vhl [nucleoplasm]
(Danio rerio)
VHL [nucleoplasm]
(Bos taurus)
VHL [nucleoplasm]
(Canis familiaris)
VHL [nucleoplasm]
(Gallus gallus)
Ghost homologue of VHL [nucleoplasm]
(Sus scrofa)
Ghost homologue of VHL [nucleoplasm]
(Xenopus tropicalis)
vhl-1 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_937799.1
,
NP_000542.1
Guide to Pharmacology - Targets
3204
OpenTargets
ENSG00000134086
ZINC - Substances
VHL_HUMAN
ZINC target
P40337
PRO
P40337
PDB
6GMX
,
4WQO
,
4W9G
,
6R6H
,
3ZTD
,
8BB2
,
8VLB
,
8BB3
,
3ZTC
,
8P0F
,
8QW7
,
8QW6
,
6GMR
,
4AWJ
,
6I7Q
,
7Z77
,
8G1Q
,
5NVY
,
6HAX
,
8CQK
,
8RX0
,
1LQB
,
5NVZ
,
6HAY
,
4W9I
,
8G1P
,
8FY2
,
8FY1
,
7CJB
,
4W9D
,
8BDX
,
3ZRF
,
6ZHC
,
6HR2
,
8PC2
,
8BDO
,
8R5H
,
8QU8
,
7PI4
,
8BDN
,
8BDJ
,
6GFY
,
6FMJ
,
8C13
,
8CQL
,
6GFZ
,
5NW1
,
8EI3
,
5NW0
,
4W9J
,
8BB4
,
1LM8
,
4W9E
,
8BB5
,
5LLI
,
4B95
,
7S4E
,
4W9F
,
4AJY
,
8VL9
,
6GMQ
,
8QJS
,
8QJR
,
8QVU
,
6GMN
,
4W9C
,
6BVB
,
4B9K
,
6I7R
,
8RWZ
,
4BKT
,
8BDI
,
6FMI
,
7KHH
,
1VCB
,
8BEB
,
4W9H
,
5NVW
,
8CQE
,
5NVX
,
7ZNT
,
3ZRC
,
5NVV
,
5T35
,
8BDT
,
8FY0
,
8BDS
,
7Q2J
,
8BDM
,
3ZUN
,
5N4W
,
8EWV
,
8BDL
,
6R7F
,
6SIS
,
4BKS
,
7Z76
,
6FMK
,
4W9K
,
7JTP
,
4W9L
,
5NW2
,
6GFX
,
7JTO
,
7Z6L
HPA
ENSG00000134086-VHL
GeneCards
P40337
Ensembl
ENSP00000256474
,
ENSP00000344757
,
ENST00000256474
,
ENSG00000134086
,
ENST00000345392
Pharos - Targets
P40337
Orphanet
15708
ZINC - Predictions - Purchasable
VHL_HUMAN
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.962
22
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.94
13
UniProt:Q13617 CUL2
3
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
CUL2 [nucleoplasm]
(R-HSA-1234126)
CUL2 [cytosol]
(R-HSA-416982)
0.916
19
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.871
10
UniProt:Q99750 MDFI
0.666
4
UniProt:Q99814 EPAS1 (HIF2A)
5
HN-EPAS1 [cytosol]
(R-HSA-1234112)
2xHP-EPAS1 [nucleoplasm]
(R-HSA-1234151)
2xHP-EPAS1 [cytosol]
(R-HSA-1234149)
EPAS1 [nucleoplasm]
(R-HSA-452560)
EPAS1 [cytosol]
(R-HSA-1234119)
0.659
3
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.623
4
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.611
9
UniProt:P0C6X7-PRO_0000037322 REP
0.602
7
UniProt:P21980 TGM2
0.602
10
UniProt:Q99873 PRMT1
2
PRMT1 [cytosol]
(R-HSA-9632173)
PRMT1 [nucleoplasm]
(R-HSA-3215140)
0.508
2
UniProt:Q61221
7
Hif1a [cytosol]
(R-MMU-1234110)
Hif1a [nucleoplasm]
(R-MMU-1234105)
Hif1a [cytosol]
(R-MMU-1234131)
phospho-Hif1a [cytosol]
(R-MMU-9634700)
phospho-Hif1a [cytosol]
(R-MMU-8857584)
Hif1a [cytosol]
(R-MMU-1234102)
Hif1a [nucleoplasm]
(R-MMU-1234135)
0.499
3
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.499
2
UniProt:Q13231 CHIT1
3
CHIT1 [specific granule lumen]
(R-HSA-6799529)
CHIT1 [extracellular region]
(R-HSA-6786396)
CHIT1 [tertiary granule lumen]
(R-HSA-6800898)
0.499
2
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.463
3
UniProt:P08151 GLI1
9
ub-GLI1 [cytosol]
(R-HSA-5635833)
ub-pS-GLI1 [ciliary base]
(R-HSA-5610514)
pS-GLI1 [ciliary base]
(R-HSA-5610497)
GLI1 [cytosol]
(R-HSA-445457)
p-GLI1 [ciliary tip]
(R-HSA-5635040)
2p-GLI1 [nucleoplasm]
(R-HSA-5635057)
p-GLI1 [nucleoplasm]
(R-HSA-5635042)
GLI1 [ciliary tip]
(R-HSA-5610360)
GLI1 [ciliary base]
(R-HSA-5610357)
0.463
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text