Reactome | VHL [nucleoplasm]

VHL [nucleoplasm]

Stable Identifier

R-HSA-1234127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of ubiquitinylation proteins (Homo sapiens)
        
        PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)
        
        VHL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40337 VHL

Gene Names

VHL

Chain

chain:1-213

Reference Genes

COSMIC (genes):VHL VHL

dbSNP Gene:7428 VHL

ENSEMBL:ENSG00000134086 VHL

Participates

as an input of

PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)

as a component of

VBC Complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K159,171,196-VHL [nucleoplasm]

VHL [cytosol]

Inferred To

Vhl [nucleoplasm] (Drosophila melanogaster)

Vhl [nucleoplasm] (Mus musculus)

Vhl [nucleoplasm] (Rattus norvegicus)

vhl [nucleoplasm] (Danio rerio)

VHL [nucleoplasm] (Bos taurus)

VHL [nucleoplasm] (Canis familiaris)

VHL [nucleoplasm] (Gallus gallus)

Ghost homologue of VHL [nucleoplasm] (Sus scrofa)

Ghost homologue of VHL [nucleoplasm] (Xenopus tropicalis)

vhl-1 [nucleoplasm] (Caenorhabditis elegans)

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.962	22
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.944	14
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.942	20
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.905	11
UniProt:Q99750 MDFI			0.666	4
UniProt:Q99814 EPAS1	5	EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112)	0.659	3
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.623	4
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.611	9
UniProt:P0C6X7-PRO_0000037322 REP			0.602	7
UniProt:P21980 TGM2			0.602	10
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.596	7
UniProt:Q8N8R7 AL14E			0.527	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.527	3
UniProt:Q6VMQ6 ATF7IP	2	me3-K16-ATF7IP [nucleoplasm] (R-HSA-9844104) ATF7IP [nucleoplasm] (R-HSA-3301918)	0.527	2
UniProt:Q99873 PRMT1	2	PRMT1 [nucleoplasm] (R-HSA-3215140) PRMT1 [cytosol] (R-HSA-9632173)	0.508	2
UniProt:Q61221	7	Hif1a [cytosol] (R-MMU-1234110) Hif1a [nucleoplasm] (R-MMU-1234105) Hif1a [cytosol] (R-MMU-1234131) Hif1a [cytosol] (R-MMU-1234102) phospho-Hif1a [cytosol] (R-MMU-9634700) phospho-Hif1a [cytosol] (R-MMU-8857584) Hif1a [nucleoplasm] (R-MMU-1234135)	0.499	3
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2477) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.499	2
UniProt:Q13231 CHIT1	3	CHIT1 [tertiary granule lumen] (R-HSA-6800898) CHIT1 [extracellular region] (R-HSA-6786396) CHIT1 [specific granule lumen] (R-HSA-6799529)	0.499	2
UniProt:P08151 GLI1	9	ub-GLI1 [cytosol] (R-HSA-5635833) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) pS-GLI1 [ciliary base] (R-HSA-5610497) GLI1 [cytosol] (R-HSA-445457) p-GLI1 [ciliary tip] (R-HSA-5635040) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [nucleoplasm] (R-HSA-5635042) GLI1 [ciliary base] (R-HSA-5610357) GLI1 [ciliary tip] (R-HSA-5610360)	0.463	2
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cell junction] (R-HSA-2134483)	0.463	3

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