VHL:EloB,C:CUL2:RBX1 [nucleoplasm]

Stable Identifier
R-HSA-1234141
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
9891082 Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

Stearman, R, Pavlakis, GN, Stauber, R, Neumann, M, Klausner, RD, Lee, S, Pause, A

Mol Cell Biol 1999
9122164 The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

Chen, DY, Worrell, RA, Burgess, WH, Lee, S, Linehan, WM, Klausner, RD, Pause, A

Proc Natl Acad Sci U S A 1997
12101228 Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

Lee, S, Groulx, I

Mol Cell Biol 2002
15601820 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kotoshiba, S, Kamura, T, Kohda, D, Maenaka, K, Nakayama, KI, Conaway, JW, Conaway, RC, Matsumoto, M

Genes Dev 2004
Participants
components
Participates
as a component of
as an input of
Inferred To
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Bos taurus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Caenorhabditis elegans)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Drosophila melanogaster)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Gallus gallus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Rattus norvegicus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Sus scrofa)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Xenopus tropicalis)
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