HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT

Stable Identifier
Reaction [binding]
Homo sapiens
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HIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) forms a heterodimer with ARNT (HIF1-beta) (Wang et al. 1995, Jiang et al. 1996, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003).

Literature References
PubMed ID Title Journal Year
14668441 Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor

Erbel, PJ, Card, PB, Karakuzu, O, Bruick, RK, Gardner, KH

Proc Natl Acad Sci U S A 2003
7539918 Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Wang, GL, Jiang, BH, Rue, EA, Semenza, GL

Proc Natl Acad Sci U S A 1995
9000051 Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Tian, H, McKnight, SL, Russell, DW

Genes Dev 1997
8663540 Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

Jiang, BH, Rue, E, Wang, GL, Roe, R, Semenza, GL

J Biol Chem 1996
9840812 Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha

Gu, YZ, Moran, SM, Hogenesch, JB, Wartman, L, Bradfield, CA

Gene Expr 1998
Orthologous Events
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