Reactome | ITGB5 [phagocytic vesicle]

ITGB5 [phagocytic vesicle]

Stable Identifier

R-HSA-1236749

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagocytic vesicle

Synonyms

Integrin beta-5

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
        
        Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)
        
        DC receptors recognizing apoptotic cells [phagocytic vesicle] (Homo sapiens)
        
        alphaVbeta5 [phagocytic vesicle] (Homo sapiens)
        
        ITGB5 [phagocytic vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18084 ITGB5

Gene Names

ITGB5

Chain

signal peptide:1-23, chain:24-799

Reference Genes

BioGPS Gene:3693 ITGB5

COSMIC (genes):ITGB5 ITGB5

CTD Gene:3693 L7RT22

dbSNP Gene:3693 ITGB5

ENSEMBL:ENSG00000082781 ITGB5

HGNC:6160 ITGB5

KEGG:hsa:3693 ITGB5

Monarch:3693 ITGB5

NCBI Gene:3693 ITGB5

OMIM:147561 ITGB5

UCSC:P18084 ITGB5

Reference Transcript

RefSeq:NM_002213.4 ITGB5

Other Identifiers

11754810_a_at

16958356

201124_PM_at

201124_at

201125_PM_s_at

201125_s_at

2058_s_at

214020_PM_x_at

2692817

2692818

2692819

2692820

2692821

2692823

2692824

2692825

2692826

2692827

2692831

2692836

2692839

2692840

2692844

2692845

2692846

2692847

2692848

2692849

2692850

2692853

2692859

2692864

2692865

2692866

2692867

2692868

2692869

2692870

2692871

2692876

2692878

2692884

3693

39754_at

8090162

A_23_P166633

GE59781

GO:0001618

GO:0005102

GO:0005178

GO:0005515

GO:0005886

GO:0005925

GO:0007010

GO:0007155

GO:0007160

GO:0007179

GO:0007229

GO:0008305

GO:0009986

GO:0016020

GO:0016477

GO:0030154

GO:0031410

GO:0034684

GO:0035313

GO:0035987

GO:0043149

GO:0043226

GO:0043235

GO:0045335

GO:0046718

GO:0046872

GO:0048870

GO:0070062

GO:0090136

GO:0098609

HMNXSV003047937

Hs.149846.0.S2_3p_at

Hs.149846.1.S1_3p_a_at

ILMN_1668374

ILMN_1701619

ILMN_1761674

ILMN_1796755

ILMN_2311166

J05633_at

PH_hs_0009022

TC03001717.hg

X53002_s_at

g4504772_3p_a_at

Participates

as a component of

alphaVbeta5 [phagocytic vesicle] (Homo sapiens)

Other forms of this molecule

ITGB5 [plasma membrane]

Inferred To

Homologues of ITGB5 [phagocytic vesicle] (Caenorhabditis elegans)

Homologues of ITGB5 [phagocytic vesicle] (Drosophila melanogaster)

Itgb5 [phagocytic vesicle] (Rattus norvegicus)

ITGB5 [phagocytic vesicle] (Bos taurus)

ITGB5 [phagocytic vesicle] (Caenorhabditis elegans)

ITGB5 [phagocytic vesicle] (Canis familiaris)

ITGB5 [phagocytic vesicle] (Gallus gallus)

ITGB5 [phagocytic vesicle] (Mus musculus)

ITGB5 [phagocytic vesicle] (Sus scrofa)

pat-3 [phagocytic vesicle] (Caenorhabditis elegans)

Itgbn [phagocytic vesicle] (Drosophila melanogaster)

mys [phagocytic vesicle] (Drosophila melanogaster)

itgb5 [phagocytic vesicle] (Danio rerio)

itgb5 [phagocytic vesicle] (Xenopus tropicalis)

Cross References

RefSeq

NP_002204.2

Guide to Pharmacology - Targets

2459

ENSEMBL

ENSG00000082781, ENST00000296181, ENSP00000296181

OpenTargets

ENSG00000082781

GeneCards

ITGB5

HPA

ENSG00000082781-ITGB5

PRO

P18084

Pharos - Targets

P18084

GlyGen

P18084

PDB

7S46, 7S47, 7S48

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BY76 ANGPTL4	3	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897) ANGPTL4(164-406) [extracellular region] (R-HSA-9762251)	0.564	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9HD67 MYO10	1	MYO10 [cytosol] (R-HSA-593679)	0.544	2
UniProt:P97479 Myo7a	1	Myo7a [cytosol] (R-MMU-9658865)	0.544	8
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.527	2