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Engulfment of particulate antigen into phagocytic vesicle
Stable Identifier
R-HSA-1236956
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
phagocytic vesicle
,
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)
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After internalization, F-actin is depolymerized from the phagosome, and the newly denuded vacuole membrane becomes accessible to early endosomes (Aderem & Underhill. 1999).
Literature References
PubMed ID
Title
Journal
Year
18331591
Contributions of proteomics to understanding phagosome maturation
Foster, LJ
,
Rogers, LD
Cell Microbiol
2008
10358769
Mechanisms of phagocytosis in macrophages
Underhill, DM
,
Aderem, A
Annu Rev Immunol
1999
Participants
Input
Particulate Ag:DC receptors [plasma membrane]
(Homo sapiens)
Output
DC receptors recognizing apoptotic cells [phagocytic vesicle]
(Homo sapiens)
Exogenous Particulate antigen (Ag) [phagocytic vesicle]
Participates
as an event of
Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
Orthologous Events
Engulfment of particulate antigen into phagocytic vesicle (Bos taurus)
Engulfment of particulate antigen into phagocytic vesicle (Caenorhabditis elegans)
Engulfment of particulate antigen into phagocytic vesicle (Canis familiaris)
Engulfment of particulate antigen into phagocytic vesicle (Danio rerio)
Engulfment of particulate antigen into phagocytic vesicle (Drosophila melanogaster)
Engulfment of particulate antigen into phagocytic vesicle (Gallus gallus)
Engulfment of particulate antigen into phagocytic vesicle (Mus musculus)
Engulfment of particulate antigen into phagocytic vesicle (Rattus norvegicus)
Engulfment of particulate antigen into phagocytic vesicle (Sus scrofa)
Engulfment of particulate antigen into phagocytic vesicle (Xenopus tropicalis)
Authored
Garapati, P V (2011-03-28)
Reviewed
English, L (2011-05-13)
Desjardins, M (2011-05-13)
Created
Garapati, P V (2011-03-28)
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