Maturation of phagosome into phagolysosome

Stable Identifier
R-HSA-1236963
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
phagocytic vesicle, phagolysosome
ReviewStatus
5/5
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Maturation of phagosome into phagolysosome
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Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.

fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.
Literature References
PubMed ID Title Journal Year
18331591 Contributions of proteomics to understanding phagosome maturation

Foster, LJ, Rogers, LD

Cell Microbiol 2008
12061891 Phagosome maturation: aging gracefully

Botelho, RJ, Vieira, OV, Grinstein, S

Biochem J 2002
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Authored
Garapati, P V  (2011-03-28)
Reviewed
English, L  (2011-05-13)
Desjardins, M  (2011-05-13)
Created
Garapati, P V  (2011-03-28)
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