Cross-presentation of soluble exogenous antigens (endosomes)

Stable Identifier
R-HSA-1236978
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cross-presentation of soluble exogenous antigens (endosomes)
Click the image above or here to open this pathway in the Pathway Browser

Exogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by distinct endocytosis mechanisms which route them into stable early endosomes and then to the cytoplasm for proteasomal degradation and peptide loading.

Literature References
PubMed ID Title Journal Year
20171863 Intracellular mechanisms of antigen cross presentation in dendritic cells

Savina, A, Amigorena, S

Curr Opin Immunol 2010
17157489 Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules

Trombetta, ES, Monu, N

Curr Opin Immunol 2007
15592474 Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells

Ackerman, AL, Kyritsis, C, Cresswell, P, Tampé, R

Nat Immunol 2005
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (0002479)
Orthologous Events
Cross-presentation of soluble exogenous antigens (endosomes) (Bos taurus)
Cross-presentation of soluble exogenous antigens (endosomes) (Caenorhabditis elegans)
Cross-presentation of soluble exogenous antigens (endosomes) (Canis familiaris)
Cross-presentation of soluble exogenous antigens (endosomes) (Danio rerio)
Cross-presentation of soluble exogenous antigens (endosomes) (Dictyostelium discoideum)
Cross-presentation of soluble exogenous antigens (endosomes) (Drosophila melanogaster)
Cross-presentation of soluble exogenous antigens (endosomes) (Gallus gallus)
Cross-presentation of soluble exogenous antigens (endosomes) (Mus musculus)
Cross-presentation of soluble exogenous antigens (endosomes) (Plasmodium falciparum)
Cross-presentation of soluble exogenous antigens (endosomes) (Rattus norvegicus)
Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
Cross-presentation of soluble exogenous antigens (endosomes) (Schizosaccharomyces pombe)
Cross-presentation of soluble exogenous antigens (endosomes) (Sus scrofa)
Cross-presentation of soluble exogenous antigens (endosomes) (Xenopus tropicalis)
Authored
Garapati, P V  (2011-03-28)
Reviewed
English, L  (2011-05-13)
Desjardins, M  (2011-05-13)
Created
Garapati, P V  (2011-03-28)
Cite Us!