Exogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by distinct endocytosis mechanisms which route them into stable early endosomes and then to the cytoplasm for proteasomal degradation and peptide loading.
Savina, A, Amigorena, S
Trombetta, ES, Monu, N
Ackerman, AL, Kyritsis, C, Cresswell, P, Tampé, R
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