Reactome | CA1 [cytosol]

CA1 [cytosol]

Stable Identifier

R-HSA-1237027

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Carbonic anhydrase 1, CAH1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q12800%20TFCP2

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of Carbonic anhydrase 1 (Homo sapiens)
        
        CA1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00915 CA1

Gene Names

CA1

Chain

initiator methionine:, chain:2-261

Reference Genes

BioGPS Gene:759 CA1

COSMIC (genes):CA1 CA1

CTD Gene:759 CA1

dbSNP Gene:759 CA1

ENSEMBL:ENSG00000133742 CA1

ENSEMBL_homo_sapiens_GENE:ENSG00000133742.14 CA1

HGNC:1368 CA1

KEGG Gene (Homo sapiens):759 CA1

Monarch:759 CA1

NCBI Gene:759 CA1

OMIM:114800 CA1

Reference Transcript

Other Identifiers

11729582_s_at

11729583_x_at

11759009_at

205949_PM_at

205949_at

205950_PM_s_at

205950_s_at

3142976

3142977

3142978

3142979

3142980

3142981

3142984

3142985

3142987

3142993

3142996

3142998

3142999

3143003

3143006

3143017

3143018

39241_at

759

8151592

A_23_P168916

GE57937

GO:0003824

GO:0004064

GO:0004089

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0006730

GO:0008270

GO:0016787

GO:0016829

GO:0016836

GO:0018820

GO:0043226

GO:0046872

GO:0070062

HMNXSV003028072

ILMN_1652431

M33987_at

PH_hs_0002029

TC08001381.hg

g179792_3p_at

g4502516_3p_a_at

Participates

as an output of

Expression of Carbonic anhydrase 1 (Homo sapiens)

as a component of

CA1:Zn2+ [cytosol] (Homo sapiens)

Inferred To

CAH3 [cytosol] (Drosophila melanogaster)

Homologues of CA1 [cytosol] (Danio rerio)

CA1 [cytosol] (Bos taurus)

CA1 [cytosol] (Canis familiaris)

CA1 [cytosol] (Danio rerio)

CA1 [cytosol] (Mus musculus)

CA1 [cytosol] (Plasmodium falciparum)

CA1 [cytosol] (Rattus norvegicus)

CA1 [cytosol] (Sus scrofa)

CA13 [cytosol] (Gallus gallus)

wu:fb50f02 [cytosol] (Danio rerio)

cah-6 [cytosol] (Caenorhabditis elegans)

ca13 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001122302.1, NP_001122303.1, NP_001122301.1, NP_001158302.1, NP_001729.1

ZINC - World Drugs

CAH1_HUMAN

Guide to Pharmacology - Targets

2597

OpenTargets

ENSG00000133742

ZINC - FDA approved

CAH1_HUMAN

ZINC - Substances

CAH1_HUMAN

ZINC - Biogenic

CAH1_HUMAN

ZINC target

P00915

PRO

P00915

PDB

6SWM, 6F3B, 5E2M, 3W6H, 6FAG, 1CZM, 6XZY, 6FAF, 6I0J, 6HWZ, 6Y00, 4WR7, 1CRM, 6I0L, 2CAB, 1J9W, 3LXE, 3W6I, 7ZL5, 6EVR, 7PLF, 5GMM, 2FOY, 1HUG, 1HUH, 6EX1, 6G3V, 2IT4, 6XZE, 2NN7, 1JV0, 1BZM, 4WUQ, 6XZX, 2FW4, 4WUP, 2NN1, 7QOB, 6XZO, 1HCB, 6XZS, 1AZM, 2NMX, 7Q0D

ZINC - Investigational

CAH1_HUMAN

ZINC - Metabolites

CAH1_HUMAN

IntEnz

4.2.1.69

HPA

ENSG00000133742-CA1

GeneCards

P00915

Ensembl

ENSP00000430656, ENST00000542576, ENST00000431316, ENSP00000392338, ENSP00000443517, ENST00000523953, ENSG00000133742, ENSP00000429798, ENST00000523022

Pharos - Targets

P00915

ZINC - Predictions - Purchasable

CAH1_HUMAN

HMDB Protein

HMDBP02057

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12800 TFCP2			0.718	6