Reactome | Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide

Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide

Stable Identifier

R-HSA-1237081

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

H+ + HCO3- -> H2O + CO2

ReviewStatus

5/5

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Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide

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Carbonic anhydrase VI (CA6) dehydrates bicarbonate to yield water and carbon dioxide (Thatcher et al. 1998, Nishimori et al. 2007). Depending on the concentrations of reactants the reaction is reversible. CA6 is a major protein of saliva and is also known as gustin.

Literature References

PubMed ID	Title	Journal	Year
17228881	Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors Nishimori, I, Supuran, CT, Scozzafava, A, Vullo, D, Onishi, S, Minakuchi, T	J Med Chem	2007
17499996	Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines Innocenti, A, Nishimori, I, Supuran, CT, Scozzafava, A, Vullo, D, Onishi, S	Bioorg Med Chem	2007
9784398	Gustin from human parotid saliva is carbonic anhydrase VI Martin, BM, Orvisky, E, Doherty, AE, Henkin, RI, Thatcher, BJ	Biochem Biophys Res Commun	1998
9336012	Structure and mechanism of carbonic anhydrase Lindskog, S	Pharmacol Ther	1997