Ligand-independent dimerization of EGFRvIII mutant

Stable Identifier
R-HSA-1248002
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands, but is able to dimerize spontaneously. Self-dimerization may be dependent on N-linked glycosylation.
Participants
Participates
Functional status

Gain of function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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