Reactome | Binding of PI3K to ERBB2:p-ERBB3 heterodimer

Binding of PI3K to ERBB2:p-ERBB3 heterodimer

Stable Identifier

R-HSA-1250189

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Binding of PI3K to ERBB2:p-ERBB3 heterodimer

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Membrane associated p85 subunit of PI3K (PIK3R1) binds to phosphorylated tyrosine residues of ERBB3 (Y1054, Y1197, Y1222, Y1224, Y1276 and Y1289) in complex with ERBB2. PIK3R1 is constitutively associated with the catalytic PI3K subunit p110 (PIK3CA). Binding of PIK3R1 to ERBB2:p-ERBB3 triggers a conformational change that activates PI3K (Yang et al. 2007, Junttila et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19411071	Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941 Junttila, TT, Fields, C, Sliwkowski, MX, Lewis Phillips, GD, Sampath, D, Friedman, LS, Parsons, K, Akita, RW	Cancer Cell	2009
17652160	Mapping ErbB receptors on breast cancer cell membranes during signal transduction Zhang, J, Yang, S, Steinberg, SL, Wilson, BS, Oliver, JM, Ying, W, Williams, L, Raymond-Stintz, MA, Lidke, DS	J Cell Sci	2007