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ROS oxidize thioredoxin
Stable Identifier
R-HSA-1250280
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
ROS oxidize thioredoxin (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
ROS oxidize thioredoxin (Homo sapiens)
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The presence of reactive oxygen species (ROS) leads to the oxidation of thioredoxin and consequent release of TXNIP (Zhou et al. 2010). The source of the ROS is unclear but they are known to be essential for caspase-1 activation (Cruz et al. 2007) and are produced in response to all known NLRP3 activators (Dostert et al. 2008, Zhou et al. 2010). The freed TXNIP binds NLRP3 and is proposed to activate the NLRP3 inflammasome, explaining how ROS can bring about NLRP3 activation.
Literature References
PubMed ID
Title
Journal
Year
20023662
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Choi, I
,
Thorens, B
,
Tardivel, A
,
Zhou, R
,
Tschopp, J
Nat Immunol
2010
Participants
Input
ROS [cytosol]
TXN [cytosol]
(Homo sapiens)
Output
2xHC-TXN [cytosol]
(Homo sapiens)
Participates
as an event of
Purinergic signaling in leishmaniasis infection (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
Orthologous Events
ROS oxidize thioredoxin (Bos taurus)
ROS oxidize thioredoxin (Caenorhabditis elegans)
ROS oxidize thioredoxin (Canis familiaris)
ROS oxidize thioredoxin (Danio rerio)
ROS oxidize thioredoxin (Dictyostelium discoideum)
ROS oxidize thioredoxin (Drosophila melanogaster)
ROS oxidize thioredoxin (Gallus gallus)
ROS oxidize thioredoxin (Mus musculus)
ROS oxidize thioredoxin (Plasmodium falciparum)
ROS oxidize thioredoxin (Rattus norvegicus)
ROS oxidize thioredoxin (Saccharomyces cerevisiae)
ROS oxidize thioredoxin (Schizosaccharomyces pombe)
ROS oxidize thioredoxin (Sus scrofa)
Authored
Jupe, S (2011-04-28)
Reviewed
Kufer, TA (2011-04-28)
Rittinger, K (2011-06-06)
Wong, E (2011-06-06)
Created
Jupe, S (2011-04-15)
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