PI3K events in ERBB4 signaling

Stable Identifier
R-HSA-1250342
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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PI3K events in ERBB4 signaling
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The CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen et al. 1996). Binding of PIK3R1 to CYT1 isoforms of ERBB4 is followed by recruitment of the p110 catalytic subunit of PI3K (PIK3CA), leading to assembly of an active PI3K complex that converts PIP2 to PIP3 and activates AKT signaling (Kainulainen et al. 2000).
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Orthologous Events
PI3K events in ERBB4 signaling (Bos taurus)
PI3K events in ERBB4 signaling (Caenorhabditis elegans)
PI3K events in ERBB4 signaling (Canis familiaris)
PI3K events in ERBB4 signaling (Danio rerio)
PI3K events in ERBB4 signaling (Drosophila melanogaster)
PI3K events in ERBB4 signaling (Gallus gallus)
PI3K events in ERBB4 signaling (Mus musculus)
PI3K events in ERBB4 signaling (Rattus norvegicus)
PI3K events in ERBB4 signaling (Sus scrofa)
PI3K events in ERBB4 signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Zeng, F  (2011-11-11)
Harris, RC  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2011-04-18)
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