Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers

Stable Identifier
R-HSA-1250370
Type
Reaction
Species
Homo sapiens
Compartment
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Activated PI3K bound to phosphorylated ERBB4 CYT-1 homodimers converts PIP2 into PIP3, which leads to activation of AKT signaling (Kainulainen et al. 2000).

Literature References
PubMed ID Title Journal Year
10722704 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis

Santiestevan, E, Sundvall, M, Kainulainen, V, Määttä, JA, Elenius, K, Klagsbrun, M

J Biol Chem 2000
Participants
Participates
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K:p-ERBB4cyt1 [plasma membrane]

Orthologous Events
Cross References
Rhea
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Created
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