PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3

Stable Identifier
R-HSA-1250462
Type
Reaction
Species
Homo sapiens
Compartment
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Activated PI3K complex directly bound to phosphorylated heterodimer of ERBB2 and ERBB3 phosphorylates PIP2 and converts it into PIP3, leading to activation of AKT signaling (Junttila et al. 2009).

Literature References
PubMed ID Title Journal Year
19411071 Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

Junttila, TT, Fields, C, Sliwkowski, MX, Lewis Phillips, GD, Sampath, D, Friedman, LS, Parsons, K, Akita, RW

Cancer Cell 2009
Participants
Participates
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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