Reactome | ERBB4jmAcyt2s80 [nucleoplasm]

ERBB4jmAcyt2s80 [nucleoplasm]

Stable Identifier

R-HSA-1252010

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-Y1172,Y1226-ERBB4-3(676-1292)

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External Reference Information

External Reference

UniProt:Q15303-3 ERBB4

Gene Names

ERBB4, HER4

Other Identifiers

11725911_a_at

11725912_a_at

11725913_a_at

16907863

1727_at

2066

206794_PM_at

206794_at

214053_PM_at

214053_at

2597563

2597564

2597565

2597566

2597567

2597568

2597569

2597570

2597571

2597580

2597581

2597583

2597584

2597586

2597609

2597615

2597616

2597617

2597621

2597623

2597626

2597628

2597629

2597631

2597632

2597633

2597635

2597636

2597637

2597638

2597646

2597661

2597684

2597720

2597788

2597789

37273_at

8058627

92081_at

A_23_P423853

A_32_P183765

A_33_P3211558

GE54083

GE575885

GE79117

GO:0000166

GO:0000976

GO:0001755

GO:0001934

GO:0003677

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005006

GO:0005154

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0007005

GO:0007165

GO:0007166

GO:0007169

GO:0007173

GO:0007259

GO:0007399

GO:0007416

GO:0007507

GO:0007595

GO:0008284

GO:0008285

GO:0009880

GO:0009925

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016323

GO:0016477

GO:0016740

GO:0018108

GO:0021551

GO:0021889

GO:0022008

GO:0023052

GO:0030154

GO:0030334

GO:0031594

GO:0034330

GO:0036211

GO:0038127

GO:0038130

GO:0038131

GO:0038135

GO:0038138

GO:0042127

GO:0042531

GO:0042734

GO:0042803

GO:0043066

GO:0043226

GO:0043235

GO:0043653

GO:0045165

GO:0045211

GO:0045893

GO:0046427

GO:0046777

GO:0048856

GO:0048870

GO:0050811

GO:0051897

GO:0060045

GO:0060089

GO:0060644

GO:0060749

GO:0061026

GO:0070374

GO:0071364

GO:0072046

GO:0098590

GO:0098839

GO:0098978

GO:0098982

GO:0099645

GO:0140096

GO:2000010

HMNXSV003010169

Hs.7888.0.S1_3p_at

ILMN_1653728

L07868_at

PH_hs_0000259

TC02002735.hg

g4885214_3p_at

Participates

as a component of

ERBB4jmAcyt2s80 dimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

ERBB4jmAcyt2s80 [mitochondrial matrix]

ERBB4jmAcyt2ECD [extracellular region]

ERBB4jmAcyt2m80 [plasma membrane]

ERBB4jmAcyt2s80 [cytosol]

p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane]

ERBB4 JM-A CYT-2 isoform [plasma membrane]

Inferred To

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Bos taurus)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Caenorhabditis elegans)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Danio rerio)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Drosophila melanogaster)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Gallus gallus)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Mus musculus)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Rattus norvegicus)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Sus scrofa)

phospho-ERBB4jmAcyt2s80 [nucleoplasm] (Xenopus tropicalis)

phospho-ERBB4 [nucleoplasm] (Canis familiaris)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1172

Coordinate

1172

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1226

Coordinate

1226

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001036064.1, XP_005246433.1, XP_005246434.1, NP_005226.1

ZINC - World Drugs

ERBB4_HUMAN

Guide to Pharmacology - Targets

1799

OpenTargets

ENSG00000178568

ZINC - FDA approved

ERBB4_HUMAN

ZINC - Substances

ERBB4_HUMAN

ZINC - Biogenic

ERBB4_HUMAN

ZINC target

Q15303

PRO

Q15303

PDB

3U9U, 2LCX, 3BCE, 3U2P, 2L2T, 3BBW, 3U7U, 3BBT, 2R4B, 2AHX

ZINC - Investigational

ERBB4_HUMAN

IntEnz

2.7.10.1

GeneCards

Q15303

HPA

ENSG00000178568-ERBB4

Ensembl

ENSG00000178568, ENST00000342788, ENST00000436443, ENSP00000403204, ENST00000260943, ENSP00000260943, ENSP00000342235

Pharos - Targets

Q15303

Orphanet

22474

ZINC - Predictions - Purchasable

ERBB4_HUMAN

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.816	5
UniProt:P78352 DLG4	3	DLG4 [cytosol] (R-HSA-6794267) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135)	0.646	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.609	6
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.589	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.577	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	7
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.573	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	3
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.553	2
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.553	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2

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