Reactome | Translocation of ERBB4s80 to the nucleus

Translocation of ERBB4s80 to the nucleus

Stable Identifier

R-HSA-1252013

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Translocation of ERBB4s80 to the nucleus

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The soluble intracellular domain of ERBB4 s80 (E4ICD) is able to translocate from the cytosol to the nucleus (Ni et al. 2001). Translocation of ERBB4s80 to the nucleus is negatively regulated by binding of ERBB4s80 to activated SRC kinase (Ishibashi et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23230144	Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src Kubota, S, Hasegawa, H, Ishibashi, K, Fukumoto, Y, Yamaguchi, N, Nakayama, Y, Abe, K, Kubota, S, Aoyama, K	J. Cell. Sci.	2013
11679632	gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase Golde, TE, Murphy, MP, Carpenter, G, Ni, CY	Science	2001