Reactome | ERBB4 ubiquitination by WWP1/ITCH

ERBB4 ubiquitination by WWP1/ITCH

Stable Identifier

R-HSA-1253282

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Upon binding to ERBB4 or its cleavage products m80 and s80, NEDD4 family ligases WWP1 and ITCH ubiquitinate intact and cleaved ERBB4 and target it for degradation (Omerovic et al. 2007, Feng et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19047365	The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation Feng, SM, Muraoka-Cook, RS, Hunter, D, Sandahl, MA, Caskey, LS, Miyazawa, K, Atfi, A, Earp HS, 3rd	Mol Cell Biol	2009
17463226	The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation Omerovic, J, Santangelo, L, Puggioni, EM, Marrocco, J, Dall'Armi, C, Palumbo, C, Belleudi, F, Di Marcotullio, L, Frati, L, Torrisi, MR, Cesareni, G, Gulino, A, Alimandi, M	FASEB J	2007