Upon binding to ERBB4 or its cleavage products m80 and s80, NEDD4 family ligases WWP1 and ITCH ubiquitinate intact and cleaved ERBB4 and target it for degradation (Omerovic et al. 2007, Feng et al. 2009).
Earp HS, 3rd, Muraoka-Cook, RS, Hunter, D, Caskey, LS, Sandahl, MA, Atfi, A, Miyazawa, K, Feng, SM
Marrocco, J, Torrisi, MR, Gulino, A, Di Marcotullio, L, Dall'Armi, C, Palumbo, C, Frati, L, Puggioni, EM, Alimandi, M, Omerovic, J, Belleudi, F, Cesareni, G, Santangelo, L
ubiquitin-protein transferase activity of ERBB4/m80/s80:WWP1/ITCH [plasma membrane]
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