Reactome | ERBB4s80:STAT5A complex translocates to the nucleus

ERBB4s80:STAT5A complex translocates to the nucleus

Stable Identifier

R-HSA-1254285

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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ERBB4s80:STAT5A complex translocates to the nucleus

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Formation of cytosolic complex of ERBB4s80 and STAT5A promotes translocation of STAT5A to the nucleus, with ERBB4s80 acting as a nuclear chaperone of STAT5A.

Literature References

PubMed ID	Title	Journal	Year
15534001	The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone Vidal, GA, Beckman, BS, Marrero, L, Jones, FE, Williams, CC, Burow, ME, Allison, JG	J Cell Biol	2004
18653779	Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation Earp HS, 3rd, Muraoka-Cook, RS, Hunter, D, Miraglia, L, Sandahl, MA	Mol Endocrinol	2008