Reactome | Translocation of cytosolic ERBB4s80 to mitochondrial matrix

Translocation of cytosolic ERBB4s80 to mitochondrial matrix

Stable Identifier

R-HSA-1254376

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix

ReviewStatus

5/5

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Translocation of cytosolic ERBB4s80 to mitochondrial matrix

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Cytosolic ERBB4s80 is able to translocate to mitochondria where its BH3 domain, characteristic of BCL2 family members, may enable it to act as a pro-apoptotic factor (Naresh et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16778220	The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells Wimley, WC, Cooke, TG, Vidal, GA, Sartor, CI, Marrero, L, Tovey, S, Jones, FE, Long, W, Bartlett, JM, Naresh, A	Cancer Res	2006