Reactome | PXLP-K259-GOT1 [cytosol]

PXLP-K259-GOT1 [cytosol]

Stable Identifier

R-HSA-1295497

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Aspartate aminotransferase, cytoplasmic, AATC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17174 GOT1

Gene Names

GOT1

Chain

initiator methionine:, chain:2-413

Reference Genes

BioGPS Gene:2805 GOT1

COSMIC (genes):GOT1 GOT1

CTD Gene:2805 GOT1

dbSNP Gene:2805 GOT1

ENSEMBL:ENSG00000120053 GOT1

HGNC:4432 GOT1

KEGG:hsa:2805 GOT1

Monarch:2805 GOT1

NCBI Gene:2805 GOT1

OMIM:138180 GOT1

UCSC:P17174 GOT1

Reference Transcript

RefSeq:NM_002079.2 GOT1

Other Identifiers

11757538_a_at

16717359

208813_PM_at

208813_at

2805

3302992

3302993

3302994

3302995

3302996

3302997

3303000

3303001

3303002

3303003

3303004

3303005

3303006

3303007

3303008

3303009

3303010

3303013

3303014

3303015

35343_at

7935627

A_23_P63825

A_24_P81473

GE57956

GO:0003824

GO:0004069

GO:0004609

GO:0005634

GO:0005737

GO:0005829

GO:0005975

GO:0006094

GO:0006103

GO:0006107

GO:0006114

GO:0006520

GO:0006531

GO:0006532

GO:0006533

GO:0006536

GO:0007219

GO:0008483

GO:0008652

GO:0009058

GO:0016740

GO:0016829

GO:0019550

GO:0019551

GO:0030170

GO:0032869

GO:0043226

GO:0047801

GO:0051384

GO:0055089

GO:0070062

HMNXSV003042732

ILMN_1656145

M37400_at

PH_hs_0000068

TC10001580.hg

g12653452_3p_at

Participates

as a component of

PXLP-K259-GOT1 dimer [cytosol] (Homo sapiens)

Inferred To

GOT1 [cytosol] (Canis familiaris)

got1 [cytosol] (Danio rerio)

got1 [cytosol] (Xenopus tropicalis)

PXLP-K259-GOT1 [cytosol] (Bos taurus)

PXLP-K259-GOT1 [cytosol] (Caenorhabditis elegans)

PXLP-K259-GOT1 [cytosol] (Gallus gallus)

PXLP-K259-GOT1 [cytosol] (Mus musculus)

PXLP-K259-GOT1 [cytosol] (Plasmodium falciparum)

PXLP-K259-GOT1 [cytosol] (Rattus norvegicus)

PXLP-K259-GOT1 [cytosol] (Saccharomyces cerevisiae)

PXLP-K259-GOT1 [cytosol] (Schizosaccharomyces pombe)

PXLP-K259-GOT1 [cytosol] (Sus scrofa)

Got1 [cytosol] (Drosophila melanogaster)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 259

Coordinate

259

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_002070.1

ENSEMBL

ENST00000370508, ENSP00000359539

OpenTargets

ENSG00000120053

IntEnz

2.6.1.3

HPA

ENSG00000120053-GOT1

PRO

P17174

Pharos - Targets

P17174

GlyGen

P17174

HMDB Protein

HMDBP00283

PDB

6DNB, 6DND, 3WZF, 6DNA, 3II0, 6LIG

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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