Activation of ATP sensitive Potassium channels in neuroendocrine cells

Stable Identifier
R-HSA-1296024
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.

Literature References
PubMed ID Title Journal Year
18258787 Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil

Shorter, K, Farjo, NP, Picksley, SM, Randall, VA

FASEB J 2008
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Participates
Catalyst Activity

potassium channel activity of ATP sensitive K+ channels (SUR1) [plasma membrane]

This event is regulated
Negatively by
Regulator
Orthologous Events
Cross References
Rhea
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