Activation of G protein gated Potassium channels

Stable Identifier
R-HSA-1296041
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of G protein gated Potassium channels
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Activation of Kir 3 channels occurs after binding of G beta gamma subunits of GPCR. Activation of Kir3/GIRK leads to K+ efflux. The dissociation of GPCR into G alpha and G beta gamma subunits is activated by the activation of GABA B receptor by GABA binding.

Literature References
PubMed ID Title Journal Year
20655490 GABAB-GIRK2-mediated signaling in Down syndrome

Cramer, NP, Siarey, RJ, Stoffel, M, Galdzicki, Z, Best, TK

Adv Pharmacol 2010
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
positive regulation of potassium ion transmembrane transport (1901381)
Orthologous Events
Activation of G protein gated Potassium channels (Bos taurus)
Activation of G protein gated Potassium channels (Caenorhabditis elegans)
Activation of G protein gated Potassium channels (Canis familiaris)
Activation of G protein gated Potassium channels (Danio rerio)
Activation of G protein gated Potassium channels (Drosophila melanogaster)
Activation of G protein gated Potassium channels (Gallus gallus)
Activation of G protein gated Potassium channels (Mus musculus)
Activation of G protein gated Potassium channels (Rattus norvegicus)
Activation of G protein gated Potassium channels (Sus scrofa)
Activation of G protein gated Potassium channels (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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