Reactome | KCNK3 [plasma membrane]

KCNK3 [plasma membrane]

Stable Identifier

R-HSA-1296326

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium channel subfamily K member 3 (TASK1), KCNK3_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Tandem pore domain potassium channels (Homo sapiens)
    - TWIK-releated acid-sensitive K+ channel (TASK) (Homo sapiens)
      - Activation of TASK (Homo sapiens)
        
        TASK [plasma membrane] (Homo sapiens)
        
        TASK 1 homomer [plasma membrane] (Homo sapiens)
        
        KCNK3 [plasma membrane] (Homo sapiens)
        
        TASK1/3 heterodimer [plasma membrane] (Homo sapiens)
        
        KCNK3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14649 KCNK3

Gene Names

KCNK3, TASK, TASK1

Chain

chain:1-394

Reference Genes

BioGPS Gene:3777 KCNK3

COSMIC (genes):KCNK3 KCNK3

CTD Gene:3777 KCNK3

dbSNP Gene:3777 KCNK3

ENSEMBL:ENSG00000171303 KCNK3

HGNC:6278 KCNK3

KEGG:hsa:3777 KCNK3

Monarch:3777 KCNK3

NCBI Entrez Gene:3777 KCNK3

OMIM:603220 KCNK3

UCSC:O14649 KCNK3

Reference Transcript

RefSeq:NM_002246.3 KCNK3

Other Identifiers

11726445_at

11726446_a_at

11726447_s_at

11752493_a_at

16877941

205952_3p_at

205952_PM_at

205952_at

228127_PM_at

228127_at

235108_PM_at

235108_at

2473890

2473891

2473937

2473938

2473939

2473940

2473941

2473942

2473943

2473944

2473945

2473946

2473947

2473948

3777

41325_at

74268_at

8040695

88977_at

A_23_P357724

A_23_P91104

A_24_P388190

A_24_P830315

GE470113

GE54075

GO:0003029

GO:0005216

GO:0005252

GO:0005267

GO:0005272

GO:0005515

GO:0005886

GO:0006811

GO:0006813

GO:0006814

GO:0007268

GO:0009410

GO:0015271

GO:0016020

GO:0022841

GO:0034220

GO:0035725

GO:0044548

GO:0045202

GO:0046872

GO:0046982

GO:0048856

GO:0051481

GO:0055085

GO:0060075

GO:0071294

GO:0071456

GO:0071468

GO:0071805

GO:0090102

GO:0099605

HMNXSV003002724

HMNXSV003034254

Hs.24040.1.S1_3p_at

Hs.290791.0.A1_3p_at

ILMN_1768483

PH_hs_0002123

TC02000153.hg

g4504848_3p_x_at

Participates

as a component of

Inferred To

Homologues of KCNK3 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNK3 [plasma membrane] (Drosophila melanogaster)

TOK1 [plasma membrane] (Saccharomyces cerevisiae)

sup-9 [plasma membrane] (Caenorhabditis elegans)

twk-20 [plasma membrane] (Caenorhabditis elegans)

Task6 [plasma membrane] (Drosophila melanogaster)

kcnk3 [plasma membrane] (Xenopus tropicalis)

Kcnk3 [plasma membrane] (Mus musculus)

Kcnk3 [plasma membrane] (Rattus norvegicus)

KCNK3 [plasma membrane] (Bos taurus)

KCNK3 [plasma membrane] (Canis familiaris)

KCNK3 [plasma membrane] (Gallus gallus)

KCNK3 [plasma membrane] (Sus scrofa)

Task7 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_002237.1

Guide to Pharmacology - Targets

515

ENSEMBL

ENSG00000171303, ENST00000302909, ENSP00000306275

OpenTargets

ENSG00000171303

ZINC - Substances

KCNK3_HUMAN

ZINC target

O14649

PRO

O14649

GlyGen

O14649

PDB

9G9X, 6RV3, 6RV2, 6RV4

GeneCards

KCNK3

HPA

ENSG00000171303-KCNK3

Pharos - Targets

O14649

Orphanet

KCNK3

ZINC - Predictions - Purchasable

KCNK3_HUMAN

HMDB Protein

HMDBP02035

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.67	5
UniProt:P35213 Ywhab	2	14-3-3 protein [cytosol] (R-RNO-182006) Ywhab [cytosol] (R-RNO-48888)	0.462	2