Tandem pore domain potassium channels

Stable Identifier
R-HSA-1296346
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Tandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mechanisms such as membrane stretch, pH, temperature. Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel).
Literature References
PubMed ID Title Journal Year
20393194 Molecular background of leak K+ currents: two-pore domain potassium channels

Czirják, G, Enyedi, P

Physiol Rev 2010
20529081 From the background to the spotlight: TASK channels in pathological conditions

Meuth, SG, Bittner, S, Wiendl, H, Budde, T

Brain Pathol 2010
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