Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Tandem pore domain potassium channels
Stable Identifier
R-HSA-1296346
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Tandem pore domain potassium channels (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
Tandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mechanisms such as membrane stretch, pH, temperature. Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel).
Literature References
PubMed ID
Title
Journal
Year
20393194
Molecular background of leak K+ currents: two-pore domain potassium channels
Czirják, G
,
Enyedi, P
Physiol Rev
2010
20529081
From the background to the spotlight: TASK channels in pathological conditions
Meuth, SG
,
Bittner, S
,
Wiendl, H
,
Budde, T
Brain Pathol
2010
Participants
Events
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
(Homo sapiens)
TWIK related potassium channel (TREK)
(Homo sapiens)
TWIK-releated acid-sensitive K+ channel (TASK)
(Homo sapiens)
TWIK-related alkaline pH activated K+ channel (TALK)
(Homo sapiens)
TWIK-related spinal cord K+ channel (TRESK)
(Homo sapiens)
Tandem pore domain halothane-inhibited K+ channel (THIK)
(Homo sapiens)
Participates
as an event of
Potassium Channels (Homo sapiens)
Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
Tandem pore domain potassium channels (Bos taurus)
Tandem pore domain potassium channels (Caenorhabditis elegans)
Tandem pore domain potassium channels (Canis familiaris)
Tandem pore domain potassium channels (Danio rerio)
Tandem pore domain potassium channels (Drosophila melanogaster)
Tandem pore domain potassium channels (Gallus gallus)
Tandem pore domain potassium channels (Mus musculus)
Tandem pore domain potassium channels (Rattus norvegicus)
Tandem pore domain potassium channels (Saccharomyces cerevisiae)
Tandem pore domain potassium channels (Sus scrofa)
Tandem pore domain potassium channels (Xenopus tropicalis)
Authored
Mahajan, SS (2011-05-19)
Reviewed
Jassal, B (2010-09-23)
Created
Mahajan, SS (2011-05-19)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text