Association of ADAM and B4GALT1 With ZP3

Stable Identifier
R-HSA-1297338
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Association of ADAM and B4GALT1 With ZP3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In humans induction of acrosome reaction is mediated by ADAM and B4GALT1 binding to ZP3 and ZP4. Binding of ZP3 to its putative sperm receptor zona receptor kinase, leads to its aggregation and downstream cAMP signaling.
Literature References
PubMed ID Title Journal Year
20364096 Fertilization: a sperm's journey to and interaction with the oocyte

Ikawa, M, Okabe, M, Inoue, N, Benham, AM

J Clin Invest 2010
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
binding of sperm to zona pellucida (0007339)
Orthologous Events
Association of ADAM and B4GALT1 With ZP3 (Bos taurus)
Association of ADAM and B4GALT1 With ZP3 (Canis familiaris)
Association of ADAM and B4GALT1 With ZP3 (Danio rerio)
Association of ADAM and B4GALT1 With ZP3 (Mus musculus)
Association of ADAM and B4GALT1 With ZP3 (Sus scrofa)
Association of ADAM and B4GALT1 With ZP3 (Xenopus tropicalis)
Authored
Gillespie, ME  (2013-02-13)
Reviewed
Lishko, PV  (2013-05-21)
Created
Gillespie, ME  (2011-05-21)
Cite Us!