Reactome | Sperm Motility And Taxes

Sperm Motility And Taxes

Stable Identifier

R-HSA-1300642

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

A series of receptor signaling pathways potentially govern chemical communication between sperm and egg, chemotactically guiding incoming sperm towards the oocyte. Though several substances are confirmed as sperm chemoattractant, progesterone (P) seems to be the best chemoattractant candidate for human sperm. Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in the female reproductive tract and by triggering key sperm physiological responses required for successful fertilization such as hyperactivated motility, chemotaxis, and the acrosome reaction. CatSper, a pH regulated, calcium selective ion channel, potassium channel KSper (Slo3), and Hv1, the voltage gated proton channel are involved in regulation of sperm hyperactivated motility. While progesterone, secreted by ovulated cumulus oophorus, may act as a chemoattractant for sperm cells over the short distances, a major determinant of sperm guidance over long distances in the mammalian female reproductive tract is rheotaxis.

Literature References

PubMed ID	Title	Journal	Year
23453951	Rheotaxis guides Mammalian sperm Miki, K, Clapham, DE	Curr. Biol.	2013
22017176	The control of male fertility by spermatozoan ion channels Ren, D, Clapham, DE, Chung, JJ, Navarro, B, Lishko, PV, Kirichok, Y	Annu. Rev. Physiol.	2012
18725941	Progesterone from the cumulus cells is the sperm chemoattractant secreted by the rabbit oocyte cumulus complex Anastasía, A, Teves, ME, Uñates, DR, Guidobaldi, HA, Giojalas, LC	PLoS ONE	2008