GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3

Stable Identifier
R-HSA-1306953
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
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Phosphorylated tyrosine residues Y1199 and Y1262 of ERBB3 in complex with ERBB2 are docking sites for GRB7 binding.
Literature References
PubMed ID Title Journal Year
9516479 Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3

Daly, RJ, Campbell, DH, Wallasch, C, Sasaki, H, Janes, PW, Fiddes, RJ, Sivertsen, SP

J Biol Chem 1998
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Orthologous Events
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GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-05-28)
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