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EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
Stable Identifier
R-HSA-1306958
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Participants
components
GRB2:GAB1 [cytosol]
(Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Homo sapiens)
Participates
as an output of
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)
as an input of
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
as a component of
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Inferred To
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Caenorhabditis elegans)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Gallus gallus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Sus scrofa)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Xenopus tropicalis)
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