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Self-ubiquitination of RNF41
Stable Identifier
R-HSA-1358789
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
Self-ubiquitination of RNF41 (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RNF41 is able to self-ubiquitinate, which keeps its levels low when ERBB3 is unstimulated.
Literature References
PubMed ID
Title
Journal
Year
12411582
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3
Qiu, XB
,
Goldberg, AL
Proc Natl Acad Sci U S A
2002
Participants
Input
RNF41 [cytosol]
(Homo sapiens)
Ub [cytosol]
(Homo sapiens)
Output
Ub-RNF41 [cytosol]
(Homo sapiens)
Participates
as an event of
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
Catalyst Activity
ubiquitin-protein transferase activity of RNF41 [cytosol]
Physical Entity
RNF41 [cytosol]
(Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Self-ubiquitination of RNF41 (Bos taurus)
Self-ubiquitination of RNF41 (Danio rerio)
Self-ubiquitination of RNF41 (Dictyostelium discoideum)
Self-ubiquitination of RNF41 (Drosophila melanogaster)
Self-ubiquitination of RNF41 (Gallus gallus)
Self-ubiquitination of RNF41 (Mus musculus)
Self-ubiquitination of RNF41 (Rattus norvegicus)
Self-ubiquitination of RNF41 (Sus scrofa)
Authored
Orlic-Milacic, M (2011-11-04)
Reviewed
Neckers, LM (2011-11-11)
Xu, W (2011-11-11)
Created
Orlic-Milacic, M (2011-06-02)
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