RNF41 ubiquitinates activated ERBB3

Stable Identifier
R-HSA-1358792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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RNF41 ubiquitinates activated ERBB3
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RNF41 ubiquitinates activated ERBB3, thereby downregulating ERBB3-mediated signaling. This reaction is part of a negative feedback loop in ERBB2:ERBB3 signaling.

Literature References
PubMed ID Title Journal Year
17210635 Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Carraway KL, 3rd, Cao, Z, Sweeney, C, Wu, X, Yen, L

Mol Cell Biol 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]

Physical Entity
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
RNF41 ubiquitinates activated ERBB3 (Bos taurus)
RNF41 ubiquitinates activated ERBB3 (Danio rerio)
RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)
RNF41 ubiquitinates activated ERBB3 (Gallus gallus)
RNF41 ubiquitinates activated ERBB3 (Mus musculus)
RNF41 ubiquitinates activated ERBB3 (Rattus norvegicus)
RNF41 ubiquitinates activated ERBB3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-06-02)
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