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DYRK1A [nucleoplasm]
Stable Identifier
R-HSA-1362267
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser for interactor UniProt:Q01826 SATB1
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)
DYRK1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13627 DYRK1A
Gene Names
DYRK1A, DYRK, MNB, MNBH
Chain
chain:1-763
Reference Genes
BioGPS Gene:1859 DYRK1A
COSMIC (genes):DYRK1A DYRK1A
CTD Gene:1859 DYRK1A
dbSNP Gene:1859 DYRK1A
ENSEMBL:ENSG00000157540 DYRK1A
ENSEMBL_homo_sapiens_GENE:ENSG00000157540.22 DYRK1A
HGNC:3091 DYRK1A
KEGG Gene (Homo sapiens):1859 DYRK1A
Monarch:1859 DYRK1A
NCBI Gene:1859 DYRK1A
OMIM:600855 DYRK1A
UCSC:Q13627 DYRK1A
Reference Transcript
RefSeq:NM_101395.2 DYRK1A
RefSeq:XM_006723977.3 DYRK1A
RefSeq:NM_130436.2 DYRK1A
RefSeq:XM_006723978.3 DYRK1A
RefSeq:NM_001347721.1 DYRK1A
RefSeq:NM_001347722.1 DYRK1A
RefSeq:NM_130438.2 DYRK1A
RefSeq:XM_011529483.2 DYRK1A
RefSeq:NM_001396.4 DYRK1A
RefSeq:XM_006723976.3 DYRK1A
RefSeq:XM_017028284.1 DYRK1A
Other Identifiers
11723614_s_at
11723615_a_at
11737527_s_at
1512_at
16922724
1859
209033_PM_s_at
209033_s_at
211079_PM_s_at
211079_s_at
211541_PM_s_at
211541_s_at
215234_PM_at
215234_at
239308_PM_at
239308_at
33946_at
36946_at
36947_s_at
3920565
3920567
3920583
3920586
3920588
3920589
3920603
3920604
3920605
3920606
3920608
3920611
3920612
3920613
3920614
3920615
3920616
3920617
3920618
3920619
3920621
3920622
3920623
3920624
3920625
3920626
3920627
3920628
3920629
3920630
3920631
3920632
3920633
3920634
3920635
3920636
3920637
3920638
3920639
3920640
75416_at
8068551
827_s_at
A_14_P123783
A_14_P133870
A_23_P211126
A_24_P62169
A_24_P935621
A_32_P852607
A_33_P3322050
A_33_P3406998
D85759_s_at
D86550_at
GE57360
GE81016
GE893872
GO:0000166
GO:0003713
GO:0003779
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005856
GO:0005874
GO:0005883
GO:0005884
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0007010
GO:0007399
GO:0007623
GO:0008092
GO:0008353
GO:0015631
GO:0016071
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0018105
GO:0018107
GO:0018108
GO:0023052
GO:0030424
GO:0030425
GO:0031115
GO:0033120
GO:0034205
GO:0036211
GO:0036289
GO:0038083
GO:0042802
GO:0043226
GO:0043518
GO:0043621
GO:0045893
GO:0046777
GO:0048025
GO:0048156
GO:0048856
GO:0050321
GO:0065003
GO:0090310
GO:0090312
GO:0106310
GO:0140096
GO:0140110
GO:0140857
GO:1990904
HMNXSV003031400
Hs.143530.0.A1_3p_at
Hs.66185.0.S1_3p_at
ILMN_1660663
ILMN_1664560
ILMN_1713599
ILMN_1794156
ILMN_1819251
ILMN_2374293
PH_hs_0004045
PH_hs_0004378
TC21000164.hg
U52373_s_at
g1663725_3p_a_at
g1772437_3p_a_at
g405724_3p_s_at
Inferred To
DYRK1A [nucleoplasm]
(Bos taurus)
DYRK1A [nucleoplasm]
(Caenorhabditis elegans)
DYRK1A [nucleoplasm]
(Canis familiaris)
DYRK1A [nucleoplasm]
(Danio rerio)
DYRK1A [nucleoplasm]
(Drosophila melanogaster)
DYRK1A [nucleoplasm]
(Gallus gallus)
DYRK1A [nucleoplasm]
(Mus musculus)
DYRK1A [nucleoplasm]
(Rattus norvegicus)
DYRK1A [nucleoplasm]
(Sus scrofa)
DYRK1A [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011527785.1
,
NP_001387.2
,
NP_569122.1
,
NP_569120.1
,
XP_016883773.1
,
XP_006724039.1
,
NP_001334651.1
,
XP_006724040.1
,
XP_006724041.1
,
NP_001334650.1
,
NP_567824.1
ZINC - World Drugs
DYR1A_HUMAN
Guide to Pharmacology - Targets
2009
OpenTargets
ENSG00000157540
ZINC - FDA approved
DYR1A_HUMAN
ZINC - Substances
DYR1A_HUMAN
ZINC target
Q13627
ZINC - Biogenic
DYR1A_HUMAN
PRO
Q13627
PDB
6S11
,
6S1J
,
7AJY
,
3ANR
,
8C3G
,
7AJA
,
6EIP
,
3ANQ
,
6S14
,
6S1H
,
6EIJ
,
7A53
,
7AJV
,
4YLJ
,
7Z5N
,
7AK2
,
6S1I
,
6UIP
,
5A4T
,
4YLK
,
7AJW
,
4AZE
,
7AJ8
,
7A5L
,
7A4Z
,
4MQ1
,
5A4E
,
6EIS
,
7A5N
,
5A4L
,
6EIV
,
7AJS
,
6EIF
,
7A5D
,
7A4R
,
5A3X
,
6EIQ
,
2WO6
,
7AJM
,
6QU2
,
6EIR
,
4NCT
,
6T6A
,
4YLL
,
6EIL
,
4YU2
,
6A1G
,
5AIK
,
2VX3
,
7A4O
,
7A5B
,
6LN1
,
7AJ7
,
6EJ4
,
7OY6
,
5A4Q
,
7AKL
,
6A1F
,
7A55
,
6UWY
,
7ZH8
,
5A54
,
7AJ4
,
7A51
,
7FHS
,
7O7K
,
6S1B
,
7AKE
,
7A4W
,
4MQ2
,
7AJ5
,
7FHT
,
8C3R
,
7A52
,
8C3Q
,
7AKA
,
6S17
,
7AJ2
,
6YF8
,
7AKB
,
7A4S
ZINC - Investigational
DYR1A_HUMAN
ZINC - Metabolites
DYR1A_HUMAN
IntEnz
2.7.12.1
GeneCards
Q13627
HPA
ENSG00000157540-DYRK1A
Ensembl
ENSG00000157540
,
ENST00000645424
,
ENSP00000381932
,
ENST00000646548
,
ENST00000644942
,
ENSP00000493627
,
ENSP00000342690
,
ENSP00000495908
,
ENSP00000381929
,
ENST00000338785
,
ENSP00000494544
,
ENSP00000496748
,
ENST00000647425
,
ENSP00000494897
,
ENST00000643624
,
ENST00000398960
,
ENST00000398956
,
ENSP00000494572
,
ENST00000647188
Pharos - Targets
Q13627
Orphanet
20280
ZINC - Predictions - Purchasable
DYR1A_HUMAN
HMDB Protein
HMDBP09525
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.935
15
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.893
8
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.798
5
UniProt:Q9BRK4 LZTS2
0.744
6
UniProt:Q9NYF3 FA53C
0.738
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.734
5
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.725
5
UniProt:Q6P1L5 F117B
0.725
4
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.725
4
UniProt:Q8NCN4 RN169
0.725
4
UniProt:P49354 FNTA
3
FNTA(59-379) [cytosol]
(R-HSA-202872)
FNTA(1-59) [cytosol]
(R-HSA-202869)
FNTA(2-379) [cytosol]
(R-HSA-2530516)
0.725
5
UniProt:P22694 PRKACB
3
PRKACB [ciliary base]
(R-HSA-5610404)
PRKACB [cytosol]
(R-HSA-57846)
PRKACB [nucleoplasm]
(R-HSA-111937)
0.725
5
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.67
4
UniProt:Q12815 TROAP
0.67
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.67
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.669
3
UniProt:P10644 PRKAR1A
4
PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713476)
PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713471)
PRKAR1A [ciliary base]
(R-HSA-5610408)
PRKAR1A [cytosol]
(R-HSA-57836)
0.643
3
UniProt:Q86VQ1 GLCI1
0.643
3
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.556
3
UniProt:P55209 NP1L1
0.547
2
UniProt:Q8IYR6 TEFF1
0.547
2
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.547
2
UniProt:P78362 SRPK2
1
SRPK2 [cytosol]
(R-HSA-9729332)
0.547
2
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.547
3
UniProt:Q14008 CKAP5
1
CKAP5 [cytosol]
(R-HSA-377729)
0.547
2
UniProt:Q00610 CLTC
10
CLTC [trans-Golgi network membrane]
(R-HSA-5333703)
CLTC [cytosol]
(R-HSA-8856820)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710852)
CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710854)
CLTC [plasma membrane]
(R-HSA-2980668)
CLTC [lysosomal membrane]
(R-HSA-2980660)
CLTC [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138450)
CLTC [endolysosome membrane]
(R-HSA-8870827)
CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710853)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710835)
0.547
2
UniProt:Q70EL1 UBP54
0.547
3
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.547
2
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.527
2
UniProt:P09496 CLTA
6
CLTA [plasma membrane]
(R-HSA-2980611)
CLTA [lysosomal membrane]
(R-HSA-2980595)
CLTA [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138427)
CLTA [endolysosome membrane]
(R-HSA-8870825)
CLTA [trans-Golgi network membrane]
(R-HSA-5333758)
CLTA [cytosol]
(R-HSA-8856817)
0.527
2
UniProt:Q6ZSY5 PPR3F
0.527
2
UniProt:O60299 LZTS3
0.527
2
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.527
3
UniProt:P49356 FNTB
1
FNTB [cytosol]
(R-HSA-2530482)
0.527
4
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.527
2
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.527
2
UniProt:Q14669 TRIP12
1
TRIP12 [cytosol]
(R-HSA-976046)
0.499
2
UniProt:Q12926 ELAVL2
1
ELAVL2 [nucleoplasm]
(R-HSA-8850864)
0.499
3
UniProt:Q9ULU4 ZMYD8
0.499
2
UniProt:Q06787 FMR1
0.499
3
UniProt:Q01826 SATB1
5
polySUMO2,3-K744-SATB1 [nucleoplasm]
(R-HSA-4615978)
monoSUMO1-K744-SATB1 [nucleoplasm]
(R-HSA-4615954)
SATB1(255-763) [nucleoplasm]
(R-HSA-352264)
SATB1(1-254) [nucleoplasm]
(R-HSA-352269)
SATB1 [nucleoplasm]
(R-HSA-201593)
0.499
2
UniProt:Q14576 ELAV3
0.499
3
UniProt:Q9Y6M1 IGF2BP2
1
IGF2BP2 [cytosol]
(R-HSA-428302)
0.499
3
UniProt:O00425 IGF2BP3
1
IGF2BP3 [cytosol]
(R-HSA-428313)
0.499
3
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.499
3
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.483
2
UniProt:Q9NRR4 DROSHA
1
DROSHA [nucleoplasm]
(R-HSA-1482510)
0.482
2
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