Reactome | DYRK1A [nucleoplasm]

DYRK1A [nucleoplasm]

Stable Identifier

R-HSA-1362267

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q6P1L5 F117B

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External Reference Information

External Reference

UniProt:Q13627 DYRK1A

Gene Names

DYRK1A, DYRK, MNB, MNBH

Chain

chain:1-763

Reference Genes

BioGPS Gene:1859 DYRK1A

COSMIC (genes):DYRK1A DYRK1A

CTD Gene:1859 DYRK1A

dbSNP Gene:1859 DYRK1A

ENSEMBL:ENSG00000157540 DYRK1A

ENSEMBL_homo_sapiens_GENE:ENSG00000157540.22 DYRK1A

HGNC:3091 DYRK1A

KEGG Gene (Homo sapiens):1859 DYRK1A

Monarch:1859 DYRK1A

NCBI Gene:1859 DYRK1A

OMIM:600855 DYRK1A

UCSC:Q13627 DYRK1A

Reference Transcript

Other Identifiers

11723614_s_at

11723615_a_at

11737527_s_at

1512_at

16922724

1859

209033_PM_s_at

209033_s_at

211079_PM_s_at

211079_s_at

211541_PM_s_at

211541_s_at

215234_PM_at

215234_at

239308_PM_at

239308_at

33946_at

36946_at

36947_s_at

3920565

3920567

3920583

3920586

3920588

3920589

3920603

3920604

3920605

3920606

3920608

3920611

3920612

3920613

3920614

3920615

3920616

3920617

3920618

3920619

3920621

3920622

3920623

3920624

3920625

3920626

3920627

3920628

3920629

3920630

3920631

3920632

3920633

3920634

3920635

3920636

3920637

3920638

3920639

3920640

75416_at

8068551

827_s_at

A_14_P123783

A_14_P133870

A_23_P211126

A_24_P62169

A_24_P935621

A_32_P852607

A_33_P3322050

A_33_P3406998

D85759_s_at

D86550_at

GE57360

GE81016

GE893872

GO:0000166

GO:0003713

GO:0003779

GO:0003824

GO:0004672

GO:0004674

GO:0004712

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005856

GO:0005874

GO:0005883

GO:0005884

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006468

GO:0007010

GO:0007399

GO:0007623

GO:0008092

GO:0008353

GO:0015631

GO:0016071

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0018107

GO:0018108

GO:0023052

GO:0030424

GO:0030425

GO:0031115

GO:0033120

GO:0034205

GO:0036211

GO:0036289

GO:0038083

GO:0042802

GO:0043226

GO:0043518

GO:0043621

GO:0045893

GO:0046777

GO:0048025

GO:0048156

GO:0048856

GO:0050321

GO:0065003

GO:0090310

GO:0090312

GO:0106310

GO:0140096

GO:0140110

GO:0140857

GO:1990904

HMNXSV003031400

Hs.143530.0.A1_3p_at

Hs.66185.0.S1_3p_at

ILMN_1660663

ILMN_1664560

ILMN_1713599

ILMN_1794156

ILMN_1819251

ILMN_2374293

PH_hs_0004045

PH_hs_0004378

TC21000164.hg

U52373_s_at

g1663725_3p_a_at

g1772437_3p_a_at

g405724_3p_s_at

Inferred To

DYRK1A [nucleoplasm] (Bos taurus)

DYRK1A [nucleoplasm] (Caenorhabditis elegans)

DYRK1A [nucleoplasm] (Canis familiaris)

DYRK1A [nucleoplasm] (Danio rerio)

DYRK1A [nucleoplasm] (Drosophila melanogaster)

DYRK1A [nucleoplasm] (Gallus gallus)

DYRK1A [nucleoplasm] (Mus musculus)

DYRK1A [nucleoplasm] (Rattus norvegicus)

DYRK1A [nucleoplasm] (Sus scrofa)

DYRK1A [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011527785.1, NP_001387.2, NP_569122.1, NP_569120.1, XP_016883773.1, XP_006724039.1, NP_001334651.1, XP_006724040.1, XP_006724041.1, NP_001334650.1, NP_567824.1

ZINC - World Drugs

DYR1A_HUMAN

Guide to Pharmacology - Targets

2009

OpenTargets

ENSG00000157540

ZINC - FDA approved

DYR1A_HUMAN

ZINC - Substances

DYR1A_HUMAN

ZINC target

Q13627

ZINC - Biogenic

DYR1A_HUMAN

PRO

Q13627

PDB

6S11, 6S1J, 7AJY, 3ANR, 8C3G, 7AJA, 6EIP, 3ANQ, 6S14, 6S1H, 6EIJ, 7A53, 7AJV, 4YLJ, 7Z5N, 7AK2, 6S1I, 6UIP, 5A4T, 4YLK, 7AJW, 4AZE, 7AJ8, 7A5L, 7A4Z, 4MQ1, 5A4E, 6EIS, 7A5N, 5A4L, 6EIV, 7AJS, 6EIF, 7A5D, 7A4R, 5A3X, 6EIQ, 2WO6, 7AJM, 6QU2, 6EIR, 4NCT, 6T6A, 4YLL, 6EIL, 4YU2, 6A1G, 5AIK, 2VX3, 7A4O, 7A5B, 6LN1, 7AJ7, 6EJ4, 7OY6, 5A4Q, 7AKL, 6A1F, 7A55, 6UWY, 7ZH8, 5A54, 7AJ4, 7A51, 7FHS, 7O7K, 6S1B, 7AKE, 7A4W, 4MQ2, 7AJ5, 7FHT, 8C3R, 7A52, 8C3Q, 7AKA, 6S17, 7AJ2, 6YF8, 7AKB, 7A4S

ZINC - Investigational

DYR1A_HUMAN

ZINC - Metabolites

DYR1A_HUMAN

IntEnz

2.7.12.1

GeneCards

Q13627

HPA

ENSG00000157540-DYRK1A

Ensembl

ENSG00000157540, ENST00000645424, ENSP00000381932, ENST00000646548, ENST00000644942, ENSP00000493627, ENSP00000342690, ENSP00000495908, ENSP00000381929, ENST00000338785, ENSP00000494544, ENSP00000496748, ENST00000647425, ENSP00000494897, ENST00000643624, ENST00000398960, ENST00000398956, ENSP00000494572, ENST00000647188

Pharos - Targets

Q13627

Orphanet

20280

ZINC - Predictions - Purchasable

DYR1A_HUMAN

HMDB Protein

HMDBP09525

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.935	15
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.893	8
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.798	5
UniProt:Q9BRK4 LZTS2			0.744	6
UniProt:Q9NYF3 FA53C			0.738	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.734	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	5
UniProt:Q6P1L5 F117B			0.725	4
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.725	4
UniProt:Q8NCN4 RN169			0.725	4
UniProt:P49354 FNTA	3	FNTA(59-379) [cytosol] (R-HSA-202872) FNTA(1-59) [cytosol] (R-HSA-202869) FNTA(2-379) [cytosol] (R-HSA-2530516)	0.725	5
UniProt:P22694 PRKACB	3	PRKACB [ciliary base] (R-HSA-5610404) PRKACB [cytosol] (R-HSA-57846) PRKACB [nucleoplasm] (R-HSA-111937)	0.725	5
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.67	4
UniProt:Q12815 TROAP			0.67	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.67	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.669	3
UniProt:P10644 PRKAR1A	4	PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A [cytosol] (R-HSA-57836)	0.643	3
UniProt:Q86VQ1 GLCI1			0.643	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:P55209 NP1L1			0.547	2
UniProt:Q8IYR6 TEFF1			0.547	2
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.547	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.547	2
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.547	3
UniProt:Q14008 CKAP5	1	CKAP5 [cytosol] (R-HSA-377729)	0.547	2
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC [plasma membrane] (R-HSA-2980668) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835)	0.547	2
UniProt:Q70EL1 UBP54			0.547	3
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.547	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.527	2
UniProt:P09496 CLTA	6	CLTA [plasma membrane] (R-HSA-2980611) CLTA [lysosomal membrane] (R-HSA-2980595) CLTA [clathrin-coated endocytic vesicle membrane] (R-HSA-5138427) CLTA [endolysosome membrane] (R-HSA-8870825) CLTA [trans-Golgi network membrane] (R-HSA-5333758) CLTA [cytosol] (R-HSA-8856817)	0.527	2
UniProt:Q6ZSY5 PPR3F			0.527	2
UniProt:O60299 LZTS3			0.527	2
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.527	3
UniProt:P49356 FNTB	1	FNTB [cytosol] (R-HSA-2530482)	0.527	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.527	2
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.527	2
UniProt:Q14669 TRIP12	1	TRIP12 [cytosol] (R-HSA-976046)	0.499	2
UniProt:Q12926 ELAVL2	1	ELAVL2 [nucleoplasm] (R-HSA-8850864)	0.499	3
UniProt:Q9ULU4 ZMYD8			0.499	2
UniProt:Q06787 FMR1			0.499	3
UniProt:Q01826 SATB1	5	polySUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) monoSUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SATB1(255-763) [nucleoplasm] (R-HSA-352264) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1 [nucleoplasm] (R-HSA-201593)	0.499	2
UniProt:Q14576 ELAV3			0.499	3
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.499	3
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.499	3
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.499	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.482	2

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