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TOP2A [nucleoplasm]
Stable Identifier
R-HSA-1362276
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)
TOP2A [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)
TOP2A [nucleoplasm] (Homo sapiens)
RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)
TOP2A [nucleoplasm] (Homo sapiens)
SUMOylation of TOP2A with SUMO1 (Homo sapiens)
TOP2A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11388 TOP2A
Gene Names
TOP2A, TOP2
Chain
chain:1-1531
Reference Genes
BioGPS Gene:7153 TOP2A
COSMIC (genes):TOP2A TOP2A
CTD Gene:7153 TOP2A
dbSNP Gene:7153 TOP2A
ENSEMBL:ENSG00000131747 TOP2A
HGNC:11989 TOP2A
KEGG:hsa:7153 TOP2A
Monarch:7153 TOP2A
NCBI Gene:7153 TOP2A
OMIM:126430 TOP2A
UCSC:P11388 TOP2A
Reference Transcript
RefSeq:NM_001067.3 TOP2A
Other Identifiers
11720970_at
11720971_at
11720972_at
1592_at
16844312
201291_PM_s_at
201291_s_at
201292_PM_at
201292_at
3756157
3756194
3756195
3756196
3756197
3756198
3756199
3756200
3756201
3756202
3756203
3756204
3756205
3756206
3756207
3756208
3756209
3756210
3756211
3756212
3756213
3756214
3756215
3756216
3756217
3756218
3756219
3756220
3756221
3756222
3756223
3756224
3756225
3756226
3756227
3756228
3756229
3756230
3756231
3756232
3756233
3756234
3756235
3756237
3756239
40145_at
59369_at
7153
74096_at
8014974
904_s_at
A_23_P118834
GE57498
GE749589
GO:0000228
GO:0000287
GO:0000712
GO:0000775
GO:0000793
GO:0000819
GO:0001673
GO:0002244
GO:0003677
GO:0003682
GO:0003723
GO:0003824
GO:0003916
GO:0003918
GO:0005080
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005814
GO:0006259
GO:0006265
GO:0006266
GO:0006355
GO:0006974
GO:0007059
GO:0007143
GO:0008094
GO:0008301
GO:0009330
GO:0016853
GO:0022414
GO:0030154
GO:0030261
GO:0030263
GO:0032991
GO:0040016
GO:0042752
GO:0042803
GO:0043065
GO:0043130
GO:0043226
GO:0045870
GO:0045944
GO:0046872
GO:0046982
GO:0048511
GO:0140013
GO:0140097
GO:0140657
GO:1905463
GO:1990904
HMNXSV003030322
Hs.156346.0.S1_3p_a_at
Hs.156346.0.S3_3p_at
ILMN_1686097
J04088_at
L47276_s_at
PH_hs_0009437
TC17001462.hg
TC17002618.hg
Participates
as an input of
SUMOylation of TOP2A with SUMO1 (Homo sapiens)
RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)
as an output of
TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)
Other forms of this molecule
polySUMO2,3-TOP2A [nucleoplasm]
monoSUMO1-K-TOP2A [nucleoplasm]
Inferred To
top2a [nucleoplasm]
(Xenopus tropicalis)
TOP2A [nucleoplasm]
(Bos taurus)
TOP2A [nucleoplasm]
(Caenorhabditis elegans)
TOP2A [nucleoplasm]
(Canis familiaris)
TOP2A [nucleoplasm]
(Dictyostelium discoideum)
TOP2A [nucleoplasm]
(Drosophila melanogaster)
TOP2A [nucleoplasm]
(Gallus gallus)
TOP2A [nucleoplasm]
(Mus musculus)
TOP2A [nucleoplasm]
(Plasmodium falciparum)
TOP2A [nucleoplasm]
(Rattus norvegicus)
TOP2A [nucleoplasm]
(Saccharomyces cerevisiae)
TOP2A [nucleoplasm]
(Schizosaccharomyces pombe)
TOP2A [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001058.2
ZINC - World Drugs
TOP2A_HUMAN
Guide to Pharmacology - Targets
2637
OpenTargets
ENSG00000131747
ENSEMBL
ENST00000423485
,
ENSP00000411532
ZINC - FDA approved
TOP2A_HUMAN
ZINC - Substances
TOP2A_HUMAN
ZINC - Biogenic
TOP2A_HUMAN
ZINC target
P11388
PRO
P11388
GlyGen
P11388
PDB
4FM9
,
5GWK
,
6ZY7
,
1ZXN
,
6ZY8
,
4R1F
,
6ZY5
,
1ZXM
,
6ZY6
,
5NNE
ZINC - Metabolites
TOP2A_HUMAN
HPA
ENSG00000131747-TOP2A
Pharos - Targets
P11388
ZINC - Predictions - Purchasable
TOP2A_HUMAN
HMDB Protein
HMDBP10697
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05655 PRKCD
12
PRKCD [cytosol]
(R-HSA-58200)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
0.679
10
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.597
4
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.597
3
UniProt:P13010 XRCC5
4
XRCC5 [nucleoplasm]
(R-HSA-58274)
XRCC5 [cytosol]
(R-HSA-3134849)
XRCC5 [secretory granule lumen]
(R-HSA-6801297)
XRCC5 [extracellular region]
(R-HSA-6806530)
0.597
3
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.597
4
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.57
5
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.564
3
UniProt:Q9UN86 G3BP2
1
G3BP2 [cytosol]
(R-HSA-9729507)
0.527
2
UniProt:P27635 RPL10
1
RPL10 [cytosol]
(R-HSA-72402)
0.527
2
UniProt:Q9Y4E5 ZN451
0.527
2
UniProt:P61313 RPL15
1
RPL15 [cytosol]
(R-HSA-72416)
0.527
2
UniProt:P36578 RPL4
1
RPL4 [cytosol]
(R-HSA-72474)
0.527
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.524
3
UniProt:O14497-1 ARID1A
0.499
2
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.483
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
8
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
UniProt:P42768 WAS
2
p-Y291-WAS [cytosol]
(R-HSA-2197668)
WAS [cytosol]
(R-HSA-201879)
0.462
2
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