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LYRM4 [mitochondrial matrix]
Stable Identifier
R-HSA-1362392
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
LYRM4 (ISD11), LYR motif-containing protein 4, LYRM4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
Transfer of Fe-S clusters to SDHB (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex III assembly (Homo sapiens)
2Fe-2S is inserted in UQCRFS1 (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
Mitochondrial iron-sulfur cluster biogenesis (Homo sapiens)
FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
Frataxin binds iron (Homo sapiens)
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
LYRM4 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HD34 LYRM4
Gene Names
LYRM4, C6orf149, ISD11, CGI-203
Chain
chain:1-91
Reference Genes
BioGPS Gene:57128 LYRM4
COSMIC (genes):LYRM4 LYRM4
CTD Gene:57128 LYRM4
dbSNP Gene:57128 LYRM4
ENSEMBL:ENSG00000214113 LYRM4
ENSEMBL_homo_sapiens_GENE:ENSG00000214113.11 LYRM4
HGNC:21365 LYRM4
KEGG Gene (Homo sapiens):57128 LYRM4
Monarch:57128 LYRM4
NCBI Gene:57128 LYRM4
OMIM:613311 LYRM4
UCSC:Q9HD34 LYRM4
Reference Transcript
RefSeq:NM_020408.5 LYRM4
RefSeq:NM_001164841.2 LYRM4
Other Identifiers
11721319_s_at
11721320_s_at
11721321_x_at
218561_PM_s_at
218561_s_at
222672_PM_at
222672_at
2939893
2939894
2939895
2939927
2939933
2939934
2939936
2939938
57128
63783_at
8123728
A_23_P254997
A_23_P32328
A_24_P312072
A_32_P116813
GE82538
GE86630
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0005829
GO:0006790
GO:0016226
GO:0016604
GO:0042803
GO:0043226
GO:0044571
GO:0044572
GO:0099128
GO:1990221
GO:1990229
HMNXSV003005183
HMNXSV003009998
HMNXSV003017408
Hs.184860.0.S2_3p_x_at
ILMN_1740927
g9966892_3p_a_at
Participates
as a component of
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
Inferred To
ISD11 [mitochondrial matrix]
(Saccharomyces cerevisiae)
Lyrm4 [mitochondrial matrix]
(Rattus norvegicus)
isd11 [mitochondrial matrix]
(Schizosaccharomyces pombe)
lyrm4 [mitochondrial matrix]
(Danio rerio)
lyrm4 [mitochondrial matrix]
(Dictyostelium discoideum)
lyrm4 [mitochondrial matrix]
(Xenopus tropicalis)
LYRM4 [mitochondrial matrix]
(Bos taurus)
LYRM4 [mitochondrial matrix]
(Caenorhabditis elegans)
LYRM4 [mitochondrial matrix]
(Canis familiaris)
LYRM4 [mitochondrial matrix]
(Gallus gallus)
LYRM4 [mitochondrial matrix]
(Mus musculus)
LYRM4 [mitochondrial matrix]
(Plasmodium falciparum)
LYRM4 [mitochondrial matrix]
(Sus scrofa)
bcn92 [mitochondrial matrix]
(Drosophila melanogaster)
Cross References
RefSeq
NP_065141.3
,
NP_001158313.1
OpenTargets
ENSG00000214113
GeneCards
Q9HD34
HPA
ENSG00000214113-LYRM4
Ensembl
ENST00000330636
,
ENSP00000418787
,
ENSG00000214113
PRO
Q9HD34
Pharos - Targets
Q9HD34
Orphanet
22801
PDB
6WIH
,
6NZU
,
6W1D
,
6WI2
,
5USR
,
7RTK
,
6UXE
,
5WLW
,
5WKP
,
5WGB
,
6ODD
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H1K1 ISCU
1
ISCU [cytosol]
(R-HSA-9771680)
0.669
7
UniProt:O14561 NDUFAB1
4
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8933545)
octanoyl-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-9857608)
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
0.643
7
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