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PXLP-K258-NFS1-1 [mitochondrial matrix]
Stable Identifier
R-HSA-1362396
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
NFS1, mitochondrial (ISCS), Cysteine desulfurase, mitochondrial, NFS1_HUMAN, NSF1 isoform 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
Transfer of Fe-S clusters to SDHB (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex III assembly (Homo sapiens)
2Fe-2S is inserted in UQCRFS1 (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
Mitochondrial iron-sulfur cluster biogenesis (Homo sapiens)
FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
Frataxin binds iron (Homo sapiens)
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
General
By analogy with yeast Hfs1, human NFS1 probably has an N-terminal transit peptide that is removed by mitochondrial processing peptidase. The cleavage site is unknown.
External Reference Information
External Reference
UniProt:Q9Y697-1 NFS1
Gene Names
NFS1, NIFS, HUSSY-08
Participates
as a component of
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
Inferred To
nfs1 [mitochondrial matrix]
(Danio rerio)
nfs1 [mitochondrial matrix]
(Xenopus tropicalis)
NFS1 [mitochondrial matrix]
(Bos taurus)
NFS1 [mitochondrial matrix]
(Canis familiaris)
NFS1 [mitochondrial matrix]
(Sus scrofa)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Dictyostelium discoideum)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Drosophila melanogaster)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Gallus gallus)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Mus musculus)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Plasmodium falciparum)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Rattus norvegicus)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Saccharomyces cerevisiae)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Schizosaccharomyces pombe)
nfs-1 [mitochondrial matrix]
(Caenorhabditis elegans)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 258
Coordinate
258
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
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