Reactome | FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix]

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix]

Stable Identifier

R-HSA-1362398

Type

Complex

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
12785837	Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins Cowan, JA, Yoon, T	J Am Chem Soc	2003
21298097	Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex Reutenauer, L, Puccio, H, Colin, F, Schmucker, S, Wattenhofer-Donzé, M, Martelli, A, Page, A	PLoS One	2011
20873749	Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex Tsai, CL, Barondeau, DP	Biochemistry	2010
11060020	Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells Tong, WH, Rouault, TA	EMBO J	2000
17331979	Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones Shan, Y, Napoli, E, Cortopassi, G	Hum Mol Genet	2007

Participants

components

Participates

as an input of

Transfer of Fe-S clusters to SDHB (Homo sapiens)

as an output of

FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)

Inferred To

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Bos taurus)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Caenorhabditis elegans)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Canis familiaris)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Danio rerio)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Dictyostelium discoideum)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Drosophila melanogaster)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Gallus gallus)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Mus musculus)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Plasmodium falciparum)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Rattus norvegicus)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Saccharomyces cerevisiae)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Schizosaccharomyces pombe)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Sus scrofa)

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Xenopus tropicalis)

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