Ubiquitination of p130 (RBL2) by SCF (Skp2)

Stable Identifier
R-HSA-1363331
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ubiquitination of p130 (RBL2) by SCF (Skp2)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2).

Literature References
PubMed ID Title Journal Year
12435635 The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)

Lukas, J, Reed, SI, Tedesco, D

Genes Dev 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm]

Physical Entity
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Caenorhabditis elegans)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Canis familiaris)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Danio rerio)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Dictyostelium discoideum)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Gallus gallus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Rattus norvegicus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Sus scrofa)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-06-14)
Cite Us!