As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2).
Lukas, J, Reed, SI, Tedesco, D
ubiquitin-protein transferase activity of p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm]
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