Expression of NPAS2

Stable Identifier
R-HSA-1368065
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
NPAS2 gene produces NPAS2
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The NPAS2 gene is transcribed to yield mRNA and the mRNA is transcribed to yield NPAS2 protein (Zhou et al. 1997, Matsumura et al. 2013, also inferred from mouse homologs). Transcription of NPAS2 is enhanced by the RORA:Coactivator complex and repressed by the REV-ERBA:Corepressor complex.

As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase). As inferred from mouse, ROR-alpha binds the promoter of the NPAS2 gene and enhances transcription.

Literature References
PubMed ID Title Journal Year
24196956 Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2)

Matsumura, R, Matsubara, C, Node, K, Takumi, T, Akashi, M

J. Biol. Chem. 2013
9012850 Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system

Zhou, YD, Barnard, M, Tian, H, Li, X, Ring, HZ, Francke, U, Shelton, J, Richardson, J, Russell, DW, McKnight, SL

Proc Natl Acad Sci U S A 1997
Participants
Participates
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!