NR1D1 (REV-ERBA) binds heme. The NR1D1:heme complex is then able to recruit the corepressors NCoR and HDAC3. Corepressors do not bind NR1D1 in the absence of heme. NR1D1:heme binds a RRE element in the promoter of the ARNTL (BMAL1) gene, recruits corepressors, and represses transcription.
Lazar, MA, Nolte, RT, Broderick, TM, Phelan, CA, Williams, SP, Hu, X, Gampe RT, Jr, Parks, DJ, Bynum, J, Montana, V, Lambert, MH
Lazar, MA, Waitt, GM, Qatanani, M, Curtin, JC, Pearce, KH, Parks, DJ, Yin, L, Reid, RA, Wu, N, Wisely, GB, Szwergold, NR
Burris, LL, Khorasanizadeh, S, Huang, P, McClure, DB, Stayrook, KR, Burris, TP, Raghuram, S, Rogers, PM, Rastinejad, F, Nosie, AK
Lazar, MA, Yin, L
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