NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors.

Stable Identifier
R-HSA-1368069
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors.
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NR1D1 (REV-ERBA) binds heme. The NR1D1:heme complex is then able to recruit the corepressors NCoR and HDAC3. Corepressors do not bind NR1D1 in the absence of heme. NR1D1:heme binds a RRE element in the promoter of the ARNTL (BMAL1) gene, recruits corepressors, and represses transcription.

Literature References
PubMed ID Title Journal Year
20581824 Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction

Lazar, MA, Nolte, RT, Broderick, TM, Phelan, CA, Williams, SP, Hu, X, Gampe RT, Jr, Parks, DJ, Bynum, J, Montana, V, Lambert, MH

Nat Struct Mol Biol 2010
18006707 Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

Lazar, MA, Waitt, GM, Qatanani, M, Curtin, JC, Pearce, KH, Parks, DJ, Yin, L, Reid, RA, Wu, N, Wisely, GB, Szwergold, NR

Science 2007
18037887 Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta

Burris, LL, Khorasanizadeh, S, Huang, P, McClure, DB, Stayrook, KR, Burris, TP, Raghuram, S, Rogers, PM, Rastinejad, F, Nosie, AK

Nat Struct Mol Biol 2007
15761026 The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene

Lazar, MA, Yin, L

Mol Endocrinol 2005
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Authored
May, B  (2011-06-22)
Reviewed
Somers, J  (2021-01-23)
Delaunay, F  (2012-01-28)
Created
May, B  (2011-06-29)
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