The CLOCK gene is transcribed to yield mRNA and the mRNA is translated to yield CLOCK protein (Steeves et al. 1999, Ueda et al. 2005, also inferred from mouse homologs). Transcription of CLOCK is repressed by REV-ERBA. The promoter of CLOCK contains an RRE element that may bind REV-ERBA and RORA.
Inferred from mouse homologs, RAI1 increases transcription of the CLOCK gene (Williams et al. 2012).