Reactome | A2M [platelet alpha granule lumen]

A2M [platelet alpha granule lumen]

Stable Identifier

R-HSA-139834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Alpha-2-macroglobulin, Alpha-2-M

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01023 A2M

Gene Names

A2M, CPAMD5, FWP007

Chain

signal peptide:1-23, chain:24-1474

Reference Genes

BioGPS Gene:2 A2M

COSMIC (genes):A2M A2M

CTD Gene:2 A2M

dbSNP Gene:2 A2M

ENSEMBL:ENSG00000175899 A2M

HGNC:7 A2M

KEGG:hsa:2 A2M

Monarch:2 A2M

NCBI Gene:2 A2M

OMIM:103950 A2M

UCSC:P01023 A2M

Reference Transcript

Other Identifiers

11715363_a_at

16761012

217757_PM_at

217757_at

3443350

3443351

3443352

3443353

3443354

3443355

3443356

3443357

3443358

3443362

3443365

3443366

3443367

3443368

3443369

3443370

3443373

3443374

3443375

3443376

3443377

3443378

3443379

3443380

3443381

3443382

3443383

3443385

3443386

3443387

3443388

3443389

3443390

3443392

3443393

3443395

3443396

3443397

3443399

3443400

3443402

3443403

3443405

3443406

3443407

3443409

3443410

3443411

3443412

3443413

3443414

3443415

3443416

3443417

3443418

3443419

3443420

3443421

3443422

3443424

3443425

3443426

3443428

3443429

3443431

3443432

3443433

72229_i_at

72231_r_at

74536_i_at

74537_f_at

75187_f_at

7960947

A_23_P116898

GE57808

GO:0001553

GO:0001869

GO:0002020

GO:0002376

GO:0002438

GO:0004866

GO:0004867

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0006953

GO:0006954

GO:0007584

GO:0010037

GO:0019838

GO:0019899

GO:0019959

GO:0019966

GO:0022414

GO:0030154

GO:0030312

GO:0031012

GO:0031093

GO:0034695

GO:0042802

GO:0043120

GO:0043226

GO:0048306

GO:0048403

GO:0048406

GO:0048856

GO:0048863

GO:0051384

GO:0062023

GO:0070062

GO:0072562

GO:0098772

GO:1990402

HMNXSV003014414

ILMN_1745607

M11313_s_at

PH_hs_0041025

TC12001187.hg

Participates

as a member of

Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

A2M [extracellular region]

Inferred To

A2M [platelet alpha granule lumen] (Canis familiaris)

A2M [platelet alpha granule lumen] (Danio rerio)

A2M [platelet alpha granule lumen] (Sus scrofa)

a2m [platelet alpha granule lumen] (Xenopus tropicalis)

si:dkey-46g23.4 [platelet alpha granule lumen] (Danio rerio)

ovos2 [platelet alpha granule lumen] (Xenopus tropicalis)

A2m [platelet alpha granule lumen] (Mus musculus)

A2m [platelet alpha granule lumen] (Rattus norvegicus)

Homologues of A2M [platelet alpha granule lumen] (Danio rerio)

Homologues of A2M [platelet alpha granule lumen] (Xenopus tropicalis)

LOC100489060 [platelet alpha granule lumen] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000175899

ENSEMBL

ENST00000318602, ENSP00000323929

HPA

ENSG00000175899-A2M

PRO

P01023

Pharos - Targets

P01023

GlyGen

P01023

PDB

7O7O, 1BV8, 7O7Q, 2P9R, 7O7N, 7O7P, 7O7L, 6TAV, 7O7R, 7O7M, 7O7S, 7VOO, 7VON

HMDB Protein

HMDBP02061

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9ULV1 FZD4	3	ub-FZD4 [plasma membrane] (R-HSA-4641182) FZD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138457) FZD4 [plasma membrane] (R-HSA-443956)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)	0.556	3
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.556	3
UniProt:P04141 CSF2 gene	1	CSF2 [extracellular region] (R-HSA-517562)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.556	3
UniProt:Q99497 PARK7	7	PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) Misfolded PARK7 [cytosol] (R-HSA-9641100) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) PARK7 [nucleoplasm] (R-HSA-3900141) monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351)	0.556	3
UniProt:Q8NBL1 POGLUT1	1	POGLUT1 [endoplasmic reticulum lumen] (R-HSA-1464796)	0.527	2
UniProt:Q9NWM8 FKBP14 gene	1	FKBP14 [endoplasmic reticulum lumen] (R-HSA-535607)	0.527	2

Cite Us!