Reactome | A2M [platelet alpha granule lumen]

A2M [platelet alpha granule lumen]

Stable Identifier

R-HSA-139834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Alpha-2-macroglobulin, Alpha-2-M

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01023 A2M

Gene Names

A2M, CPAMD5, FWP007

Chain

signal peptide:1-23, chain:24-1474

Reference Genes

BioGPS Gene:2 A2M

COSMIC (genes):A2M A2M

CTD Gene:2 A2M

dbSNP Gene:2 A2M

ENSEMBL:ENSG00000175899.15 A2M

HGNC:7 A2M

KEGG Gene (Homo sapiens):2 A2M

Monarch:2 A2M

NCBI Gene:2 A2M

OMIM:103950 A2M

UCSC:P01023 A2M

Reference Transcript

Other Identifiers

11715363_a_at

16761012

217757_PM_at

217757_at

3443351

3443352

3443353

3443355

3443356

3443358

3443362

3443366

3443367

3443368

3443369

3443370

3443374

3443377

3443379

3443380

3443381

3443383

3443385

3443386

3443387

3443388

3443390

3443392

3443393

3443395

3443396

3443397

3443400

3443402

3443403

3443405

3443406

3443407

3443409

3443410

3443411

3443412

3443413

3443415

3443416

3443419

3443422

3443424

3443425

3443426

3443431

3443432

3443433

74536_i_at

74537_f_at

75187_f_at

7960947

A_23_P116898

GE57808

GO:0001553

GO:0001869

GO:0002020

GO:0002376

GO:0002438

GO:0004866

GO:0004867

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006953

GO:0006954

GO:0007584

GO:0010037

GO:0010466

GO:0010951

GO:0019838

GO:0019899

GO:0019959

GO:0019966

GO:0022414

GO:0030154

GO:0030312

GO:0030414

GO:0031012

GO:0031093

GO:0031410

GO:0034695

GO:0042802

GO:0043120

GO:0043226

GO:0048306

GO:0048403

GO:0048406

GO:0048856

GO:0048863

GO:0051384

GO:0062023

GO:0070062

GO:0072562

GO:0098542

GO:0098772

GO:1990402

HMNXSV003014414

ILMN_1745607

M11313_s_at

PH_hs_0041025

TC12001187.hg

Participates

as a member of

Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

A2M [extracellular region]

Inferred To

gpr37 [platelet alpha granule lumen] (Xenopus tropicalis)

Tep4 [platelet alpha granule lumen] (Drosophila melanogaster)

A2M [platelet alpha granule lumen] (Caenorhabditis elegans)

A2M [platelet alpha granule lumen] (Danio rerio)

A2M [platelet alpha granule lumen] (Sus scrofa)

Mcr [platelet alpha granule lumen] (Drosophila melanogaster)

A2m [platelet alpha granule lumen] (Mus musculus)

A2m [platelet alpha granule lumen] (Rattus norvegicus)

Homologues of A2M [platelet alpha granule lumen] (Caenorhabditis elegans)

Homologues of A2M [platelet alpha granule lumen] (Danio rerio)

Homologues of A2M [platelet alpha granule lumen] (Drosophila melanogaster)

Tep2 [platelet alpha granule lumen] (Drosophila melanogaster)

Tep3 [platelet alpha granule lumen] (Drosophila melanogaster)

Tep1 [platelet alpha granule lumen] (Drosophila melanogaster)

tep-1 [platelet alpha granule lumen] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001334353.1, NP_001334354.1, NP_001334352.1, NP_000005.2

OpenTargets

ENSG00000175899

HPA

ENSG00000175899-A2M

GeneCards

P01023

Ensembl

ENSG00000175899, ENSP00000323929, ENST00000318602

PRO

P01023

Pharos - Targets

P01023

Orphanet

26464

HMDB Protein

HMDBP02061

PDB

7O7S, 6TAV, 7O7Q, 2P9R, 7O7M, 1BV8, 7O7P, 7O7R, 7O7O, 7O7N

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q9ULV1 FZD4	3	ub-FZD4 [plasma membrane] (R-HSA-4641182) FZD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138457) FZD4 [plasma membrane] (R-HSA-443956)	0.556	3
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:P04141 CSF2	1	CSF2 [extracellular region] (R-HSA-517562)	0.556	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y396-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3

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