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A2M [platelet alpha granule lumen]
Stable Identifier
R-HSA-139834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Alpha-2-macroglobulin, Alpha-2-M
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
A2M [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01023 A2M
Gene Names
A2M, CPAMD5, FWP007
Chain
signal peptide:1-23, chain:24-1474
Reference Genes
BioGPS Gene:2 A2M
COSMIC (genes):A2M A2M
CTD Gene:2 A2M
dbSNP Gene:2 A2M
ENSEMBL:ENSG00000175899 A2M
ENSEMBL:ENSG00000175899.15 A2M
HGNC:7 A2M
KEGG Gene (Homo sapiens):2 A2M
Monarch:2 A2M
NCBI Gene:2 A2M
OMIM:103950 A2M
UCSC:P01023 A2M
Reference Transcript
RefSeq:NM_001347424.1 A2M
RefSeq:NM_001347423.1 A2M
RefSeq:NM_000014.5 A2M
RefSeq:NM_001347425.1 A2M
Other Identifiers
11715363_a_at
16761012
2
217757_PM_at
217757_at
3443351
3443352
3443353
3443355
3443356
3443358
3443362
3443366
3443367
3443368
3443369
3443370
3443374
3443377
3443379
3443380
3443381
3443383
3443385
3443386
3443387
3443388
3443390
3443392
3443393
3443395
3443396
3443397
3443400
3443402
3443403
3443405
3443406
3443407
3443409
3443410
3443411
3443412
3443413
3443415
3443416
3443419
3443422
3443424
3443425
3443426
3443431
3443432
3443433
74536_i_at
74537_f_at
75187_f_at
7960947
A_23_P116898
GE57808
GO:0001553
GO:0001869
GO:0002020
GO:0002376
GO:0002438
GO:0004866
GO:0004867
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0006953
GO:0006954
GO:0007584
GO:0010037
GO:0010466
GO:0010951
GO:0019838
GO:0019899
GO:0019959
GO:0019966
GO:0022414
GO:0030154
GO:0030312
GO:0030414
GO:0031012
GO:0031093
GO:0031410
GO:0034695
GO:0042802
GO:0043120
GO:0043226
GO:0048306
GO:0048403
GO:0048406
GO:0048856
GO:0048863
GO:0051384
GO:0062023
GO:0070062
GO:0072562
GO:0098542
GO:0098772
GO:1990402
HMNXSV003014414
ILMN_1745607
M11313_s_at
PH_hs_0041025
TC12001187.hg
Participates
as a member of
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
Other forms of this molecule
A2M [extracellular region]
Inferred To
gpr37 [platelet alpha granule lumen]
(Xenopus tropicalis)
Tep4 [platelet alpha granule lumen]
(Drosophila melanogaster)
A2M [platelet alpha granule lumen]
(Caenorhabditis elegans)
A2M [platelet alpha granule lumen]
(Danio rerio)
A2M [platelet alpha granule lumen]
(Sus scrofa)
Mcr [platelet alpha granule lumen]
(Drosophila melanogaster)
A2m [platelet alpha granule lumen]
(Mus musculus)
A2m [platelet alpha granule lumen]
(Rattus norvegicus)
Homologues of A2M [platelet alpha granule lumen]
(Caenorhabditis elegans)
Homologues of A2M [platelet alpha granule lumen]
(Danio rerio)
Homologues of A2M [platelet alpha granule lumen]
(Drosophila melanogaster)
Tep2 [platelet alpha granule lumen]
(Drosophila melanogaster)
Tep3 [platelet alpha granule lumen]
(Drosophila melanogaster)
Tep1 [platelet alpha granule lumen]
(Drosophila melanogaster)
fa56g11 [platelet alpha granule lumen]
(Danio rerio)
tep-1 [platelet alpha granule lumen]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000005.2
,
NP_001334352.1
,
NP_001334353.1
,
NP_001334354.1
OpenTargets
ENSG00000175899
HPA
ENSG00000175899-A2M
GeneCards
P01023
Ensembl
ENSP00000323929
,
ENST00000318602
,
ENSG00000175899
PRO
P01023
Pharos - Targets
P01023
Orphanet
26464
HMDB Protein
HMDBP02061
PDB
7O7M
,
7O7O
,
6TAV
,
7O7L
,
2P9R
,
7O7P
,
7VON
,
1BV8
,
7O7Q
,
7VOO
,
7O7R
,
7O7N
,
7O7S
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULV1 FZD4
3
ub-FZD4 [plasma membrane]
(R-HSA-4641182)
FZD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138457)
FZD4 [plasma membrane]
(R-HSA-443956)
0.556
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.556
3
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.556
3
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
LYN [cytosol]
(R-HSA-354251)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:Q99497 PARK7
7
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
PARK7 [nucleoplasm]
(R-HSA-3900141)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
0.556
3
UniProt:P04141 CSF2
1
CSF2 [extracellular region]
(R-HSA-517562)
0.556
3
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