Binding of Syk tyrosine kinase

Stable Identifier
R-HSA-139842
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Binding of Syk tyrosine kinase
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Syk binds to the phosphorylated ITAM motif of Fc epsilon R1 gamma chain, each SH2 domain binding a phosphorylated tyrosine. Unlike Zap70, Syk appears to autophosphorylate, so does not require Src family kinases for activation.
Participants
Input
Output
Participates
as an event of
Orthologous Events
Binding of Syk tyrosine kinase (Bos taurus)
Binding of Syk tyrosine kinase (Canis familiaris)
Binding of Syk tyrosine kinase (Mus musculus)
Binding of Syk tyrosine kinase (Rattus norvegicus)
Binding of Syk tyrosine kinase (Sus scrofa)
Binding of Syk tyrosine kinase (Xenopus tropicalis)
Created
Farndale, R  (2004-09-25)
Pace, NP  (2004-09-25)
de Bono, B  (2004-09-25)
Cite Us!