Reactome | HGF(32-494) [platelet alpha granule lumen]

HGF(32-494) [platelet alpha granule lumen]

Stable Identifier

R-HSA-139866

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

HGF, Hepatocyte growth factor precursor, Scatter factor, SF, Hepatopoeitin A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14210 HGF

Gene Names

HGF, HPTA

Chain

signal peptide:1-31, chain:32-494, chain:495-728

Reference Genes

BioGPS Gene:3082 HGF

COSMIC (genes):HGF HGF

CTD Gene:3082 HGF

dbSNP Gene:3082 HGF

ENSEMBL:ENSG00000019991 HGF

HGNC:4893 HGF

KEGG:hsa:3082 HGF

Monarch:3082 HGF

NCBI Gene:3082 HGF

OMIM:142409 HGF

UCSC:P14210 HGF

Reference Transcript

Participates

as a component of

Hepatocyte growth factor [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

HGF(32-494) [extracellular region]

HGF(495-728) [extracellular region]

pro-HGF [extracellular region]

HGF(495-728) [platelet alpha granule lumen]

Inferred To

HGF [platelet alpha granule lumen] (Bos taurus)

HGF [platelet alpha granule lumen] (Canis familiaris)

HGF [platelet alpha granule lumen] (Sus scrofa)

Hgf [platelet alpha granule lumen] (Mus musculus)

Hgf [platelet alpha granule lumen] (Rattus norvegicus)

HGF(32-494) [platelet alpha granule lumen] (Caenorhabditis elegans)

HGF(32-494) [platelet alpha granule lumen] (Gallus gallus)

hgf [platelet alpha granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001010931.1, XP_011514417.1, XP_006716019.1, XP_016867587.1, XP_016867586.1, NP_001010934.1, NP_001010933.1, NP_001010932.1, NP_000592.3

OpenTargets

ENSG00000019991

ENSEMBL

ENSP00000408270, ENST00000453411, ENSP00000413829, ENST00000423064, ENST00000457544, ENST00000222390, ENST00000444829, ENSP00000222390, ENSG00000019991, ENSP00000391238, ENSP00000389854

ZINC - Substances

HGF_HUMAN

ZINC target

P14210

PRO

P14210

GlyGen

P14210

PDB

1GP9, 1SI5, 3MKP, 4O3U, 1GMN, 5CT1, 1BHT, 4D3C, 1SHY, 4K3J, 4O3T, 1GMO, 5CP9, 7MOA, 3HMT, 7MO9, 7MOB, 5CT2, 7MO7, 3HN4, 5CSQ, 5CT3, 7MO8, 5COE, 3HMS, 3SP8, 7OCM, 7OCL, 2QJ2, 5CS9, 1NK1, 2HGF, 5CS3, 5CS5, 5CS1

HPA

ENSG00000019991-HGF

GeneCards

HGF

Pharos - Targets

P14210

Orphanet

HGF

ZINC - Predictions - Purchasable

HGF_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032)	0.851	7
UniProt:P14210 HGF	5	HGF(32-494) [extracellular region] (R-HSA-56497) HGF(495-728) [extracellular region] (R-HSA-141767) pro-HGF [extracellular region] (R-HSA-6800218) HGF(495-728) [platelet alpha granule lumen] (R-HSA-141764) HGF(32-494) [platelet alpha granule lumen] (R-HSA-139866)	0.623	2
UniProt:P16056	7	phospho-p-Y1349,Y1356-MET [plasma membrane] (R-MMU-6807032) phospho-p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-MMU-6807014) phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-MMU-8875181) phospho-MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-MMU-8875180) phospho-p-Y1003,4Y-MET [plasma membrane] (R-MMU-8874689) MET [plasma membrane] (R-MMU-419603) phospho-p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-MMU-6806973)	0.558	2
UniProt:P50222 MEOX2			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3

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