Phosphorylation of DLC2 by MAPK8

Stable Identifier
R-HSA-139908
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of DLC2 by MAPK8
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MAPK8 (JNK) phosphorylates BMF on a DLC binding motif DKATQTLSP involved in interaction with dynein DYNLL2 (DLC2), which sequesters BMF to the cytoskeleton. Phosphorylated BMF dissociates from dynein. Two JNK consensus sites exist in BMF: S74 and S77 (Lei and Davis 2003).

Literature References
PubMed ID Title Journal Year
12591950 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Davis, RJ, Lei, K

Proc Natl Acad Sci U S A 2003
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Catalyst Activity

protein serine/threonine kinase activity of MAPK8 [cytosol]

Physical Entity
MAPK8 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of DLC2 by MAPK8 (Bos taurus)
Phosphorylation of DLC2 by MAPK8 (Canis familiaris)
Phosphorylation of DLC2 by MAPK8 (Danio rerio)
Phosphorylation of DLC2 by MAPK8 (Gallus gallus)
Phosphorylation of DLC2 by MAPK8 (Mus musculus)
Phosphorylation of DLC2 by MAPK8 (Rattus norvegicus)
Phosphorylation of DLC2 by MAPK8 (Sus scrofa)
Phosphorylation of DLC2 by MAPK8 (Xenopus tropicalis)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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