tBID activates BAX protein

Stable Identifier
R-HSA-139917
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
During certain types of apoptosis, activated tBID (p15) induces a change in conformation of Bax which leads to the unmasking of its NH2-terminal domain. This change in confirmation usually results in the release of cytochrome c from mitochondria.
Literature References
PubMed ID Title Journal Year
10629050 Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

Desagher, S, Eskes, R, Martinou, JC, Antonsson, B

Mol Cell Biol 2000
Participants
Participates
Orthologous Events
Authored
Created
Cite Us!