Phosphorylation of BIM by JNK

Stable Identifier
R-HSA-139918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
MAPK8 phosphorylates BCL2L11
ReviewStatus
5/5
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Phosphorylation of BIM by JNK
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MAPK8 (JNK) phosphorylates BCL2L11 (BIM) on a DLC-binding motif (DKSTQTP), involved in dynein (DYNLL2 i.e. DLC1) binding and sequestration of BCL2L11 (BIM) to the cytoskeleton. Phosphorylated BCL2L11 dissociates from dynein. Three sites in BCL2L11 match the JNK consensus: S44, T56 and S58 in BCL2L11 isoform BimL (these residues correspond to S104, T116 and S118 in BCL2L11 isoform BimEL), and all sites appear to be phosphorylated by MAPK8 (JNK) both in vitro and in vivo (Lei and Davis 2003).
Literature References
PubMed ID Title Journal Year
12591950 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Davis, RJ, Lei, K

Proc Natl Acad Sci U S A 2003
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Catalyst Activity

protein serine/threonine kinase activity of MAPK8 [cytosol]

Physical Entity
MAPK8 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of BIM by JNK (Bos taurus)
Phosphorylation of BIM by JNK (Canis familiaris)
Phosphorylation of BIM by JNK (Gallus gallus)
Phosphorylation of BIM by JNK (Mus musculus)
Phosphorylation of BIM by JNK (Rattus norvegicus)
Phosphorylation of BIM by JNK (Sus scrofa)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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