Reactome | p-BCL2L11 [cytosol]

p-BCL2L11 [cytosol]

Stable Identifier

R-HSA-140525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-BIM

Locations in the PathwayBrowser for interactor UniProt:Q07820 MCL1

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External Reference Information

External Reference

UniProt:O43521 BCL2L11

Gene Names

BCL2L11, BIM

Chain

chain:1-198

Reference Genes

BioGPS Gene:10018 BCL2L11

COSMIC (genes):BCL2L11 BCL2L11

CTD Gene:10018 BCL2L11

dbSNP Gene:10018 BCL2L11

ENSEMBL:ENSG00000153094 BCL2L11

HGNC:994 BCL2L11

KEGG:hsa:10018 BCL2L11

Monarch:10018 BCL2L11

NCBI Gene:10018 BCL2L11

OMIM:603827 BCL2L11

UCSC:O43521 BCL2L11

Reference Transcript

Participates

as an input of

Translocation of BIM to mitochondria (Homo sapiens)

as an output of

Phosphorylation of BIM by JNK (Homo sapiens)

Other forms of this molecule

BCL2L11 [cytosol]

p-BCL2L11 [mitochondrial outer membrane]

p-S69-BCL2L11 [cytosol]

BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]

BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]

BCL2L11 [mitochondrial outer membrane]

Inferred To

phospho-BCL2L11 [cytosol] (Canis familiaris)

phospho-p-BCL2L11 [cytosol] (Bos taurus)

phospho-p-BCL2L11 [cytosol] (Gallus gallus)

phospho-p-BCL2L11 [cytosol] (Sus scrofa)

phospho-Bcl2l11 [cytosol] (Mus musculus)

phospho-Bcl2l11 [cytosol] (Rattus norvegicus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

OpenTargets

ENSG00000153094

ENSEMBL

ENST00000415458, ENST00000308659, ENSP00000411137, ENSP00000309226, ENSP00000412892, ENST00000437029, ENST00000436733, ENST00000405953, ENST00000439718, ENSP00000403727, ENST00000452231, ENSP00000384641, ENST00000431217, ENSG00000153094, ENSP00000391292, ENST00000393256, ENSP00000393781, ENSP00000394640, ENSP00000376943

GeneCards

BCL2L11

HPA

ENSG00000153094-BCL2L11

PRO

O43521

Pharos - Targets

O43521

PDB

5VWX, 6RJP, 4D2M, 5VWY, 5C3G, 6UA3, 5VWZ, 2VM6, 4B4S, 3D7V, 2YQ6, 3IO9, 6UAB, 5WOS, 6VBX, 2YQ7, 4ZIE, 6X8O, 3FDL, 1F95, 5VWV, 5VWW, 3KJ2, 8T5E, 4ZIH, 3IO8, 4A1U, 4QVF, 5VX0, 4ZIF, 2V6Q, 2WH6, 4A1W, 5VX2, 6TQQ, 4UF3, 5VX3, 2NL9, 4YJ4, 5AGW, 5AGX, 6QFI, 3KJ1, 3KJ0, 2K7W

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.948	19
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.943	22
UniProt:Q07817-1 BCL2L1			0.935	10
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.926	11
UniProt:Q92843 B2CL2			0.901	10
UniProt:Q9HD36 B2L10			0.832	11
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.826	11
UniProt:P97287 MCL1			0.796	7
UniProt:Q16548 BCL2A1	1	BCL2A1 [cytosol] (R-HSA-9725307)	0.683	4
UniProt:P68451 PG045			0.621	4
UniProt:Q07440 B2LA1			0.609	2
UniProt:O43521 BCL2L11	7	BCL2L11 [cytosol] (R-HSA-2976673) p-BCL2L11 [cytosol] (R-HSA-140525) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674)	0.589	2
UniProt:Q07813-1 BAX			0.558	7
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:P03495 NS1			0.508	2
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.499	2

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